LipidDB ID

LipidDB-9606-00193

Entry Name

UniProt Accession

Q6MZT1; B7Z3X1;

Theoretical PI

8.79

Molecular Weight

28962.09

Genbank Protein ID

BAH12357.1; EAW51372.1; AAI40708.1; CAE45947.1;

Genbank Nucleotide ID

AK296443; AC091862; AC035143; AC008854; CH471137; BC140707; BX640900;

Protein Name

Regulator of G-protein signaling 7-binding protein

Protein Synonyms/Alias

R7 family-binding protein;

Gene Name

RGS7BP

Gene Synonyms/Alias

R7BP;

Created Date

15-MAY-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ.Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novelmembrane anchor for the RGS7 family. J Cell Biol. 2005 May 23;169(4):623-33. Epub2005 May 16.[PMID:15897264]

Functional Description

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity).

Sequence Annotation

Motif: 242 247 Nuclear localization signal.

Protein Length

257 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW

Interpro

InterPro; IPR026512; RGS7BP/RGS9BP

Pfam

SMART

PROSITE

PRINTS