LipidDB ID

LipidDB-9606-00187

Entry Name

UniProt Accession

Q99523; B4DWI3; C0JYZ0; Q8IZ49;

Theoretical PI

5.46

Molecular Weight

92067.69

Genbank Protein ID

CAA66904.2; ACN81319.1; BAG63045.1; CAI13180.1; AAH23542.1;

Genbank Nucleotide ID

X98248; FJ525881; AK301548; AL390252; BC023542;

Protein Name

Sortilin

Protein Synonyms/Alias

100 kDa NT receptor; Glycoprotein 95; Gp95; Neurotensin receptor 3; NT3; NTR3;

Gene Name

SORT1

Gene Synonyms/Alias

Created Date

01-DEC-2000

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G, LefrancoisS. Palmitoylation controls recycling in lysosomal sorting and trafficking.Traffic. 2008 Nov;9(11):1984-97. doi: 10.1111/j.1600-0854.2008.00814.x. Epub 2008Aug 9.[PMID:18817523]

Functional Description

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Sequence Annotation

Topological domain: 78 755 Extracellular.
Transmembrane: 756 778 Helical.
Topological domain: 779 831 Cytoplasmic.
Region: 50 61 Intrachain binding of the propeptide andthe extracellular domain.
Region: 612 756 Interactions with LRPAP1 and NGFB.
Region: 779 831 Golgi to endosome transport andinteractions with GGA1 and GGA2.
Motif: 787 792 Endocytosis signal.
Modified residue: 819 819 Phosphoserine.
Modified residue: 825 825 Phosphoserine.

Protein Length

831 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0030136; C:clathrin-coated vesicle; IDA:BHF-UCL
GO:0005905; C:coated pit; IDA:BHF-UCL
GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:BHF-UCL
GO:0005769; C:early endosome; IDA:BHF-UCL
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IDA:BHF-UCL
GO:0016021; C:integral component of membrane; IDA:BHF-UCL
GO:0005764; C:lysosome; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl
GO:0019899; F:enzyme binding; IPI:BHF-UCL
GO:0048406; F:nerve growth factor binding; IPI:BHF-UCL
GO:0010465; F:nerve growth factor receptor activity; IDA:BHF-UCL
GO:0030379; F:neurotensin receptor activity, non-G-protein coupled; IDA:BHF-UCL
GO:0006897; P:endocytosis; IDA:BHF-UCL
GO:0008333; P:endosome to lysosome transport; IDA:BHF-UCL
GO:0032509; P:endosome transport via multivesicular body sorting pathway; IDA:BHF-UCL
GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:BHF-UCL
GO:0046323; P:glucose import; IMP:BHF-UCL
GO:0006895; P:Golgi to endosome transport; IDA:BHF-UCL
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW
GO:0014902; P:myotube differentiation; IMP:BHF-UCL
GO:0051005; P:negative regulation of lipoprotein lipase activity; IDA:BHF-UCL
GO:0038180; P:nerve growth factor signaling pathway; IDA:GOC
GO:0007218; P:neuropeptide signaling pathway; IDA:BHF-UCL
GO:0048011; P:neurotrophin TRK receptor signaling pathway; IMP:BHF-UCL
GO:0001503; P:ossification; IEA:UniProtKB-KW
GO:0048227; P:plasma membrane to endosome transport; IDA:BHF-UCL
GO:0010468; P:regulation of gene expression; IMP:BHF-UCL
GO:0032868; P:response to insulin; IMP:BHF-UCL
GO:0016050; P:vesicle organization; IDA:BHF-UCL

Interpro

InterPro; IPR006581; VPS10
InterPro; IPR015943; WD40/YVTN_repeat-like_dom

Pfam

SMART

SMART; SM00602; VPS10;

PROSITE

PRINTS