| Tag |
Content |
LipidDB ID |
LipidDB-9606-00167 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.51 |
Molecular Weight |
126368.12 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
BTB/POZ domain-containing protein 7 |
Protein Synonyms/Alias |
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Gene Name |
BTBD7 |
Gene Synonyms/Alias |
KIAA1525; |
Created Date |
07-JUN-2005 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGANASNYP | [1] | N-Myristoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[ PMID:20213681]
|
Functional Description |
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). |
Sequence Annotation |
Domain: 142 211 BTB 1.
Domain: 247 341 BTB 2.
Domain: 413 479 BACK.
|
Protein Length |
1132 AA. |
Protein Sequence
(Canonical) |
MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT 60
SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL 120
ARPEARTLQK DMADLYEYKY CTDVDLIFQE TCFPVHRAIL AARCPFFKTL LSSSPEYGAE 180
IIMDINTAGI DMPMFSALLH YLYTGEFGME DSRFQNVDIL VQLSEEFGTP NSLDVDMRGL 240
FDYMCYYDVV LSFSSDSELV EAFGGNQNCL DEELKAHKAV ISARSPFFRN LLQRRIRTGE 300
EITDRTLRTP TRIILDESII PKKYATVILH CMYTDVVDLS VLHCSPSVGS LSEVQALVAG 360
KPNMTRAEEA MELYHIALFL EFNMLAQGCE DIIAESISLD TLIAILKWSS HPYGSKWVHR 420
QALHFLCEEF SQVMTSDVFY ELSKDHLLTA IQSDYLQASE QDILKYLIKW GEHQLMKRIA 480
DREPNLLSGT AHSVNKRGVK RRDLDMEELR EILSSLLPFV RIEHILPINS EVLSDAMKRG 540
LISTPPSDML PTTEGGKSNA WLRQKNAGIY VRPRLFSPYV EEAKSVLDEM MVEQTDLVRL 600
RMVRMSNVPD TLYMVNNAVP QCCHMISHQQ ISSNQSSPPS VVANEIPVPR LLIMKDMVRR 660
LQELRHTEQV QRAYALNCGE GATVSYEIQI RVLREFGLAD AAAELLQNPH KFFPDERFGD 720
ESPLLTMRQP GRCRVNSTPP AETMFTDLDS FVAFHPPLPP PPPPYHPPAT PIHNQLKAGW 780
KQRPPSQHPS RSFSYPCNHS LFHSRTAPKA GPPPVYLPSV KAAPPDCTST AGLGRQTVAA 840
AAATTTSTAT AAAAAASEKQ VRTQPVLNDL MPDIAVGVST LSLKDRRLPE LAVDTELSQS 900
VSEAGPGPPQ HLSCIPQRHT HTSRKKHTLE QKTDTRENPQ EYPDFYDFSN AACRPSTPAL 960
SRRTPSPSQG GYFGPDLYSH NKASPSGLKS AYLPGQTSPK KQEEARREYP LSPDGHLHRQ 1020
KNEPIHLDVV EQPPQRSDFP LAAPENASTG PAHVRGRTAV ETDLTFGLTP NRPSLSACSS 1080
EAPEERSGRR LADSESLGHG AQRNTDLERE DSISRGRRSP SKPDFLYKKS AL 1132
|
FASTA
(Canonical) |
>LipidDB-9606-00167|Q9P203
MGANASNYPHSCSPRVGGNSQAQQTFIGTSSYSQQGYGCESKLYSLDHGHEKPQDKKKRT
SGLATLKKKFIKRRKSNRSADHAKQMRELLSGWDVRDVNALVEEYEGTSALKELSLQASL
ARPEARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAE
IIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDILVQLSEEFGTPNSLDVDMRGL
FDYMCYYDVVLSFSSDSELVEAFGGNQNCLDEELKAHKAVISARSPFFRNLLQRRIRTGE
EITDRTLRTPTRIILDESIIPKKYATVILHCMYTDVVDLSVLHCSPSVGSLSEVQALVAG
KPNMTRAEEAMELYHIALFLEFNMLAQGCEDIIAESISLDTLIAILKWSSHPYGSKWVHR
QALHFLCEEFSQVMTSDVFYELSKDHLLTAIQSDYLQASEQDILKYLIKWGEHQLMKRIA
DREPNLLSGTAHSVNKRGVKRRDLDMEELREILSSLLPFVRIEHILPINSEVLSDAMKRG
LISTPPSDMLPTTEGGKSNAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRL
RMVRMSNVPDTLYMVNNAVPQCCHMISHQQISSNQSSPPSVVANEIPVPRLLIMKDMVRR
LQELRHTEQVQRAYALNCGEGATVSYEIQIRVLREFGLADAAAELLQNPHKFFPDERFGD
ESPLLTMRQPGRCRVNSTPPAETMFTDLDSFVAFHPPLPPPPPPYHPPATPIHNQLKAGW
KQRPPSQHPSRSFSYPCNHSLFHSRTAPKAGPPPVYLPSVKAAPPDCTSTAGLGRQTVAA
AAATTTSTATAAAAAASEKQVRTQPVLNDLMPDIAVGVSTLSLKDRRLPELAVDTELSQS
VSEAGPGPPQHLSCIPQRHTHTSRKKHTLEQKTDTRENPQEYPDFYDFSNAACRPSTPAL
SRRTPSPSQGGYFGPDLYSHNKASPSGLKSAYLPGQTSPKKQEEARREYPLSPDGHLHRQ
KNEPIHLDVVEQPPQRSDFPLAAPENASTGPAHVRGRTAVETDLTFGLTPNRPSLSACSS
EAPEERSGRRLADSESLGHGAQRNTDLEREDSISRGRRSPSKPDFLYKKSAL
|
Gene Ontology |
GO:0005634; C:nucleus; ISS:UniProtKB GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW GO:0060693; P:regulation of branching involved in salivary gland morphogenesis; IEA:Ensembl |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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