Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00159
Entry Name
UniProt Accession
Theoretical PI
6.42
Molecular Weight
54815.53
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Thyroid hormone receptor alpha
Protein Synonyms/Alias
Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha;
Gene Name
THRA
Gene Synonyms/Alias
EAR7; ERBA1; NR1A1; THRA1; THRA2;
Created Date
01-JUL-1989
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
254
Canonical
QIILLKGCCMEIMSL
[1]
S-Palmitoylation
255
Canonical
IILLKGCCMEIMSLR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB. Nongenomic thyroid hormonesignaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014May 20;7(326):ra48. doi: 10.1126/scisignal.2004911.[PMID:24847117]
Functional Description
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Sequence Annotation
Region: 1 52 Modulating.
Region: 190 370 Ligand-binding.
Binding site: 228 228 Thyroid hormone.
Binding site: 277 277 Thyroid hormone; via amide nitrogen.
Protein Length
490 AA.
Protein Sequence
(Canonical)
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA  60
TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM  120
AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA  180
QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS  240
ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF  300
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI  360
PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL  420
GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC  480
EDLAGNAASP                                                         490
FASTA
(Canonical)
>LipidDB-9606-00159|P10827
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
Gene Ontology
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0005654; C:nucleoplasm; TAS:Reactome
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0031490; F:chromatin DNA binding; IEA:Ensembl
GO:0019904; F:protein domain specific binding; IPI:UniProtKB
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB
GO:0003707; F:steroid hormone receptor activity; IEA:InterPro
GO:0002153; F:steroid receptor RNA activator RNA binding; IEA:Ensembl
GO:0017025; F:TBP-class protein binding; IDA:UniProtKB
GO:0070324; F:thyroid hormone binding; IDA:UniProtKB
GO:0004887; F:thyroid hormone receptor activity; IDA:UniProtKB
GO:0008134; F:transcription factor binding; IPI:UniProtKB
GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL
GO:0008270; F:zinc ion binding; IEA:InterPro
GO:0001502; P:cartilage condensation; IEA:Ensembl
GO:0042994; P:cytoplasmic sequestering of transcription factor; IEA:Ensembl
GO:0030218; P:erythrocyte differentiation; IEA:Ensembl
GO:0008050; P:female courtship behavior; IEA:Ensembl
GO:0010467; P:gene expression; TAS:Reactome
GO:0009755; P:hormone-mediated signaling pathway; IDA:BHF-UCL
GO:0007611; P:learning or memory; IEA:Ensembl
GO:2000143; P:negative regulation of DNA-templated transcription, initiation; IDA:UniProtKB
GO:0017055; P:negative regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:UniProtKB
GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB
GO:0001503; P:ossification; IEA:Ensembl
GO:0045925; P:positive regulation of female receptivity; IEA:Ensembl
GO:0010831; P:positive regulation of myotube differentiation; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0008016; P:regulation of heart contraction; IEA:Ensembl
GO:0050994; P:regulation of lipid catabolic process; IEA:Ensembl
GO:0033032; P:regulation of myeloid cell apoptotic process; IEA:Ensembl
GO:0002155; P:regulation of thyroid hormone mediated signaling pathway; IEA:Ensembl
GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL
GO:0009409; P:response to cold; IEA:Ensembl
GO:0030878; P:thyroid gland development; IEA:Ensembl
GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB
GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome
GO:0060509; P:Type I pneumocyte differentiation; IEA:Ensembl
Interpro
InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core
InterPro; IPR001723; Str_hrmn_rcpt
InterPro; IPR001728; ThyrH_rcpt
InterPro; IPR001628; Znf_hrmn_rcpt
InterPro; IPR013088; Znf_NHR/GATA
Pfam
Pfam; PF00104; Hormone_recep;
Pfam; PF00105; zf-C4;
SMART
SMART; SM00430; HOLI;
SMART; SM00399; ZnF_C4;
PROSITE
PROSITE; PS00031; NUCLEAR_REC_DBD_1;
PROSITE; PS51030; NUCLEAR_REC_DBD_2;
PRINTS
PRINTS; PR00398; STRDHORMONER;
PRINTS; PR00047; STROIDFINGER;
PRINTS; PR00546; THYROIDHORMR;