Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00157
Entry Name
UniProt Accession
Theoretical PI
8.44
Molecular Weight
27991.61
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
B-cell receptor-associated protein 31
Protein Synonyms/Alias
BCR-associated protein 31; Bap31; 6C6-AG tumor-associated antigen; Protein CDM; p28;
Gene Name
BCAP31
Gene Synonyms/Alias
BAP31; DXS1357E;
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
165
Canonical
KKGAAVDGGKLDVGN
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Martin DD, Vilas GL, Prescher JA, Rajaiah G, Falck JR, Bertozzi CR, BerthiaumeLG. Rapid detection, discovery, and identification of post-translationallymyristoylated proteins during apoptosis using a bio-orthogonal azidomyristateanalog. FASEB J. 2008 Mar;22(3):797-806. Epub 2007 Oct 10.[PMID:17932026]
Functional Description
Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.
Sequence Annotation
Topological domain: 2 6 Lumenal.
Transmembrane: 7 27 Helical.
Topological domain: 28 43 Cytoplasmic.
Transmembrane: 44 64 Helical.
Topological domain: 65 102 Lumenal.
Transmembrane: 103 123 Helical.
Topological domain: 124 246 Cytoplasmic.
Motif: 243 246 Di-lysine motif.
Functional site: 164 165 Cleavage; by caspase-8.
Functional site: 238 239 Cleavage; by caspase-8.
Protein Length
246 AA.
Protein Sequence
(Canonical)
MSLQWTAVAT FLYAEVFVVL LLCIPFISPK RWQKIFKSRL VELLVSYGNT FFVVLIVILV  60
LLVIDAVREI RKYDDVTEKV NLQNNPGAME HFHMKLFRAQ RNLYIAGFSL LLSFLLRRLV  120
TLISQQATLL ASNEAFKKQA ESASEAAKKY MEENDQLKKG AAVDGGKLDV GNAEVKLEEE  180
NRSLKADLQK LKDELASTKQ KLEKAENQVL AMRKQSEGLT KEYDRLLEEH AKLQAAVDGP  240
MDKKEE                                                             246
FASTA
(Canonical)
>LipidDB-9606-00157|P51572
MSLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILV
LLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLV
TLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAVDGGKLDVGNAEVKLEEE
NRSLKADLQKLKDELASTKQKLEKAENQVLAMRKQSEGLTKEYDRLLEEHAKLQAAVDGP
MDKKEE
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome
GO:0000139; C:Golgi membrane; IEA:Ensembl
GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0005811; C:lipid particle; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome
GO:0006915; P:apoptotic process; TAS:Reactome
GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IMP:UniProtKB
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl
GO:0006886; P:intracellular protein transport; IEA:InterPro
GO:0032471; P:negative regulation of endoplasmic reticulum calcium ion concentration; IMP:UniProtKB
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:UniProtKB
GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB
GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IMP:UniProtKB
GO:0070973; P:protein localization to endoplasmic reticulum exit site; IEA:Ensembl
GO:0007283; P:spermatogenesis; IEA:Ensembl
Interpro
InterPro; IPR008417; BAP29/BAP31
Pfam
SMART
PROSITE
PRINTS