LipidDB ID

LipidDB-9606-00151

Entry Name

UniProt Accession

P60033; P18582; Q5U0J6;

Theoretical PI

5.09

Molecular Weight

25809.4

Genbank Protein ID

AAA36663.1; AAV38314.1; AAV38315.1; ABK41932.1; AAH02978.1; AAH93047.1;

Genbank Nucleotide ID

M33680; BT019507; BT019508; EF064749; AC129929; AC124057; BC002978; BC093047;

Protein Name

CD81 antigen

Protein Synonyms/Alias

26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD81;

Gene Name

CD81

Gene Synonyms/Alias

TAPA1; TSPAN28;

Created Date

21-NOV-2003

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Clark KL, Oelke A, Johnson ME, Eilert KD, Simpson PC, Todd SC. CD81 associateswith 14-3-3 in a redox-regulated palmitoylation-dependent manner. J Biol Chem.2004 May 7;279(19):19401-6. Epub 2004 Feb 13.[PMID:14966136]
[2] Delandre C, Penabaz TR, Passarelli AL, Chapes SK, Clem RJ. Mutation ofjuxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and altersinteraction with other proteins at the cell surface. Exp Cell Res. 2009 Jul1;315(11):1953-63. doi: 10.1016/j.yexcr.2009.03.013. Epub 2009 Mar 25. PubMedPMID: 19328198; PubMed Central PMCID: PMC2785499.[PMID:19328198]
[3] Zhu YZ, Luo Y, Cao MM, Liu Y, Liu XQ, Wang W, Wu DG, Guan M, Xu QQ, Ren H,Zhao P, Qi ZT. Significance of palmitoylation of CD81 on its association withtetraspanin-enriched microdomains and mediating hepatitis C virus cell entry.Virology. 2012 Aug 1;429(2):112-23. doi: 10.1016/j.virol.2012.03.002. Epub 2012May 4.[PMID:22560863]

Functional Description

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

Sequence Annotation

Topological domain: 1 12 Cytoplasmic.
Transmembrane: 13 33 Helical.
Topological domain: 34 63 Extracellular.
Transmembrane: 64 84 Helical.
Topological domain: 85 89 Cytoplasmic.
Transmembrane: 90 112 Helical.
Topological domain: 113 201 Extracellular.
Transmembrane: 202 224 Helical.
Topological domain: 225 236 Cytoplasmic.

Protein Length

236 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0001772; C:immunological synapse; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB
GO:0000187; P:activation of MAPK activity; IDA:UniProtKB
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB
GO:0046488; P:phosphatidylinositol metabolic process; IDA:UniProtKB
GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; IDA:UniProtKB
GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB
GO:0008104; P:protein localization; IDA:UniProtKB
GO:0046813; P:receptor-mediated virion attachment to host cell; TAS:UniProtKB
GO:0050776; P:regulation of immune response; TAS:Reactome
GO:0046718; P:viral entry into host cell; TAS:UniProtKB

Interpro

InterPro; IPR028977; CD81_LEL
InterPro; IPR000301; Tetraspanin
InterPro; IPR018499; Tetraspanin/Peripherin
InterPro; IPR018503; Tetraspanin_CS
InterPro; IPR008952; Tetraspanin_EC2

Pfam

Pfam; PF00335; Tetraspannin;

SMART

PROSITE

PROSITE; PS00421; TM4_1;

PRINTS

PRINTS; PR00259; TMFOUR;