LipidDB ID

LipidDB-9606-00145

Entry Name

UniProt Accession

O95372; Q7Z4Z2;

Theoretical PI

6.74

Molecular Weight

24736.95

Genbank Protein ID

AAC72844.1; AAP97210.1; CAB40158.1; AAH17034.1; AAH17193.1;

Genbank Nucleotide ID

AF098668; AF090423; AL031295; BC017034; BC017193;

Protein Name

Acyl-protein thioesterase 2

Protein Synonyms/Alias

APT-2; 3.1.2.-; Lysophospholipase II; LPL-II; LysoPLA II;

Gene Name

LYPLA2

Gene Synonyms/Alias

APT2;

Created Date

16-JAN-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, Mukherjee AB. Dynamicpalmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product andgrowth-associated protein-43. J Biol Chem. 2013 Mar 29;288(13):9112-25. doi:10.1074/jbc.M112.421073. Epub 2013 Feb 8.[PMID:23396970]

Functional Description

May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.

Sequence Annotation

Active site: 122 122 Charge relay system.
Active site: 176 176 Charge relay system.
Active site: 210 210 Charge relay system.

Protein Length

231 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW
GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW

Interpro

InterPro; IPR029058; AB_hydrolase
InterPro; IPR003140; PLipase/COase/thioEstase

Pfam

Pfam; PF02230; Abhydrolase_2;

SMART

PROSITE

PRINTS