LipidDB ID

LipidDB-9606-00137

Entry Name

UniProt Accession

P21731; O75228; Q6DK52; Q9UCY1; Q9UCY2;

Theoretical PI

10.0

Molecular Weight

37431.1

Genbank Protein ID

BAA07274.1; BAA03649.1; AAA58957.1; AAA68608.1; AAR07905.1; ABB72549.1; AAC24302.1; AAC24303.1; EAW69301.1; AAH74749.1; AAH74750.1;

Genbank Nucleotide ID

D38081; D15056; U11271; U27325; AY429110; DQ268653; AC005175; AC005175; CH471139; BC074749; BC074750;

Protein Name

Thromboxane A2 receptor

Protein Synonyms/Alias

TXA2-R; Prostanoid TP receptor;

Gene Name

TBXA2R

Gene Synonyms/Alias

Created Date

01-MAY-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Reid HM, Kinsella BT. Palmitoylation of the TPbeta isoform of the humanthromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization. Cell Signal. 2007 May;19(5):1056-70. Epub 2006 Dec 12.[PMID:17229546]

Functional Description

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Sequence Annotation

Topological domain: 1 29 Extracellular.
Transmembrane: 30 52 Helical; Name=1.
Topological domain: 53 66 Cytoplasmic.
Transmembrane: 67 87 Helical; Name=2.
Topological domain: 88 106 Extracellular.
Transmembrane: 107 128 Helical; Name=3.
Topological domain: 129 149 Cytoplasmic.
Transmembrane: 150 172 Helical; Name=4.
Topological domain: 173 193 Extracellular.
Transmembrane: 194 219 Helical; Name=5.
Topological domain: 220 246 Cytoplasmic.
Transmembrane: 247 270 Helical; Name=6.
Topological domain: 271 289 Extracellular.
Transmembrane: 290 311 Helical; Name=7.
Topological domain: 312 343 Cytoplasmic.
Modified residue: 329 329 Phosphoserine.

Protein Length

343 AA.

Protein Sequence
(Isoform 2)

FASTA
(Isoform 2)

Gene Ontology

GO:0001669; C:acrosomal vesicle; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome
GO:0004961; F:thromboxane A2 receptor activity; TAS:ProtInc
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0006954; P:inflammatory response; IEA:Ensembl
GO:0030168; P:platelet activation; TAS:Reactome
GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl
GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl
GO:0043547; P:positive regulation of GTPase activity; TAS:GOC
GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl
GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl
GO:0042493; P:response to drug; IEA:Ensembl
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl
GO:0007584; P:response to nutrient; IEA:Ensembl
GO:0019932; P:second-messenger-mediated signaling; IEA:Ensembl
GO:0038193; P:thromboxane A2 signaling pathway; TAS:GOC

Interpro

InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR008365; Prostanoid_rcpt
InterPro; IPR001105; Thbox_rcpt

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR01788; PROSTANOIDR;
PRINTS; PR00429; THROMBOXANER;