LipidDB ID

LipidDB-9606-00136

Entry Name

UniProt Accession

P05023; B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21;

Theoretical PI

5.33

Molecular Weight

112896.1

Genbank Protein ID

BAA00061.1; CAA27840.1; AAC50131.1; BAH11971.1; BAH12332.1; BAG37313.1; EAW56644.1; AAH03077.1; AAH01330.1; AAH50359.1; AAA51801.1; AAA51801.1; AAA92713.1; AAD56251.1; AAD56252.1; AAA51803.1; AAA35573.1; AAA35574.2; CAA27390.1;

Genbank Nucleotide ID

D00099; X04297; U16798; AK295095; AK296362; AK314777; AL136376; CH471122; BC003077; BC001330; BC050359; M30310; M30309; L76938; M16793; M16794; J03007; M27572; M27579; X03757;

Protein Name

Sodium/potassium-transporting ATPase subunit alpha-1

Protein Synonyms/Alias

Na(+)/K(+) ATPase alpha-1 subunit; 3.6.3.9; Sodium pump subunit alpha-1;

Gene Name

ATP1A1

Gene Synonyms/Alias

Created Date

13-AUG-1987

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Sequence Annotation

Topological domain: 6 87 Cytoplasmic.
Transmembrane: 88 108 Helical.
Topological domain: 109 131 Extracellular.
Transmembrane: 132 152 Helical.
Topological domain: 153 288 Cytoplasmic.
Transmembrane: 289 308 Helical.
Topological domain: 309 320 Extracellular.
Transmembrane: 321 338 Helical.
Topological domain: 339 772 Cytoplasmic.
Transmembrane: 773 792 Helical.
Topological domain: 793 802 Extracellular.
Transmembrane: 803 823 Helical.
Topological domain: 824 843 Cytoplasmic.
Transmembrane: 844 866 Helical.
Topological domain: 867 918 Extracellular.
Transmembrane: 919 938 Helical.
Topological domain: 939 951 Cytoplasmic.
Transmembrane: 952 970 Helical.
Topological domain: 971 985 Extracellular.
Transmembrane: 986 1006 Helical.
Topological domain: 1007 1023 Cytoplasmic.
Region: 82 84 Phosphoinositide-3 kinase binding.
Active site: 376 376 4-aspartylphosphate intermediate.
Metal binding site: 717 717 Magnesium.
Metal binding site: 721 721 Magnesium.
Binding site: 487 487 ATP.
Modified residue: 9 9 N6-acetyllysine.
Modified residue: 10 10 Phosphotyrosine.
Modified residue: 16 16 Phosphoserine.
Modified residue: 21 21 N6-acetyllysine.
Modified residue: 260 260 Phosphotyrosine.
Modified residue: 542 542 Phosphotyrosine.
Modified residue: 661 661 N6-succinyllysine.
Modified residue: 943 943 Phosphoserine; by PKA.

Protein Length

1023 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0016323; C:basolateral plasma membrane; IEA:Ensembl
GO:0005901; C:caveola; IEA:Ensembl
GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL
GO:0005768; C:endosome; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; ISS:BHF-UCL
GO:0016021; C:integral component of membrane; ISS:UniProtKB
GO:0016020; C:membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0043234; C:protein complex; IDA:MGI
GO:0042383; C:sarcolemma; ISS:BHF-UCL
GO:0005890; C:sodium:potassium-exchanging ATPase complex; IDA:BHF-UCL
GO:0030315; C:T-tubule; IEA:Ensembl
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0043531; F:ADP binding; IEA:Ensembl
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0051087; F:chaperone binding; IPI:BHF-UCL
GO:0016791; F:phosphatase activity; IEA:Ensembl
GO:0030955; F:potassium ion binding; IEA:Ensembl
GO:0031402; F:sodium ion binding; IEA:Ensembl
GO:0005391; F:sodium:potassium-exchanging ATPase activity; ISS:UniProtKB
GO:1990239; F:steroid hormone binding; IDA:BHF-UCL
GO:0006754; P:ATP biosynthetic process; IEA:InterPro
GO:0060048; P:cardiac muscle contraction; TAS:BHF-UCL
GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; TAS:BHF-UCL
GO:0030007; P:cellular potassium ion homeostasis; IDA:BHF-UCL
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl
GO:0071383; P:cellular response to steroid hormone stimulus; IDA:BHF-UCL
GO:0006883; P:cellular sodium ion homeostasis; IDA:BHF-UCL
GO:0034220; P:ion transmembrane transport; TAS:Reactome
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl
GO:0086009; P:membrane repolarization; IDA:BHF-UCL
GO:0086013; P:membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL
GO:0031947; P:negative regulation of glucocorticoid biosynthetic process; IEA:Ensembl
GO:0045822; P:negative regulation of heart contraction; IEA:Ensembl
GO:0045823; P:positive regulation of heart contraction; IEA:Ensembl
GO:0045989; P:positive regulation of striated muscle contraction; IEA:Ensembl
GO:0010107; P:potassium ion import; IDA:BHF-UCL
GO:0008217; P:regulation of blood pressure; IEA:Ensembl
GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl
GO:0002028; P:regulation of sodium ion transport; ISS:UniProtKB
GO:0002026; P:regulation of the force of heart contraction; IEA:Ensembl
GO:0055119; P:relaxation of cardiac muscle; TAS:BHF-UCL
GO:0042493; P:response to drug; IEA:Ensembl
GO:0036376; P:sodium ion export from cell; IDA:BHF-UCL
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR006068; ATPase_P-typ_cation-transptr_C
InterPro; IPR004014; ATPase_P-typ_cation-transptr_N
InterPro; IPR023299; ATPase_P-typ_cyto_domN
InterPro; IPR005775; ATPase_P-typ_Na/K_IIC
InterPro; IPR018303; ATPase_P-typ_P_site
InterPro; IPR023298; ATPase_P-typ_TM_dom
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A
InterPro; IPR001757; Cation_transp_P_typ_ATPase
InterPro; IPR023214; HAD-like_dom

Pfam

Pfam; PF00689; Cation_ATPase_C;
Pfam; PF00690; Cation_ATPase_N;
Pfam; PF00122; E1-E2_ATPase;
Pfam; PF00702; Hydrolase;

SMART

SMART; SM00831; Cation_ATPase_N;

PROSITE

PROSITE; PS00154; ATPASE_E1_E2;

PRINTS

PRINTS; PR00119; CATATPASE;