Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00123
Entry Name
UniProt Accession
Theoretical PI
6.67
Molecular Weight
165282.52
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Glutamate receptor ionotropic, NMDA 2A
Protein Synonyms/Alias
GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A;
Gene Name
GRIN2A
Gene Synonyms/Alias
NMDAR2A;
Created Date
01-JUN-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
848
Canonical
FYWKLRFCFTGVCSD
[1]
S-Palmitoylation
853
Canonical
RFCFTGVCSDRPGLL
[1]
S-Palmitoylation
870
Canonical
ISRGIYSCIHGVHIE
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hayashi T, Thomas GM, Huganir RL. Dual palmitoylation of NR2 subunitsregulates NMDA receptor trafficking. Neuron. 2009 Oct 29;64(2):213-26. doi:10.1016/j.neuron.2009.08.017.[PMID:19874789]
Functional Description
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
Sequence Annotation
Topological domain: 23 555 Extracellular.
Transmembrane: 556 576 Helical.
Topological domain: 577 633 Cytoplasmic.
Transmembrane: 634 654 Helical.
Topological domain: 655 816 Extracellular.
Transmembrane: 817 837 Helical.
Topological domain: 838 1464 Cytoplasmic.
Region: 511 513 Glutamate binding.
Region: 689 690 Glutamate binding.
Motif: 1462 1464 PDZ-binding.
Metal binding site: 128 128 Zinc.
Metal binding site: 283 283 Zinc.
Binding site: 518 518 Glutamate.
Binding site: 731 731 Glutamate; via amide nitrogen.
Functional site: 614 614 Functional determinant of NMDA receptors.
Protein Length
1464 AA.
Protein Sequence
(Canonical)
MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA  60
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT  120
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY  180
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL  240
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT  300
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR  360
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE  420
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV  480
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS  540
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT  600
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD  660
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL  720
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL  780
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL  840
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS  900
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM  960
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS  1020
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH  1080
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT  1140
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH  1200
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP  1260
ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL  1320
EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG  1380
RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS  1440
TPRVLNSCSN RRVYKKMPSI ESDV                                         1464
FASTA
(Canonical)
>LipidDB-9606-00123|Q12879
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV
Gene Ontology
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0009986; C:cell surface; ISS:BHF-UCL
GO:0030425; C:dendrite; IBA:RefGenome
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:UniProtKB
GO:0097481; C:neuronal postsynaptic density; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0045211; C:postsynaptic membrane; IBA:RefGenome
GO:0042734; C:presynaptic membrane; IEA:Ensembl
GO:0008021; C:synaptic vesicle; IEA:Ensembl
GO:0005262; F:calcium channel activity; IEA:Ensembl
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome
GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; IBA:RefGenome
GO:0008270; F:zinc ion binding; ISS:UniProtKB
GO:0033058; P:directional locomotion; IEA:Ensembl
GO:0042417; P:dopamine metabolic process; IEA:Ensembl
GO:0007215; P:glutamate receptor signaling pathway; TAS:ProtInc
GO:0034220; P:ion transmembrane transport; IBA:RefGenome
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IBA:RefGenome
GO:0007611; P:learning or memory; TAS:ProtInc
GO:0007613; P:memory; IEA:Ensembl
GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl
GO:0022008; P:neurogenesis; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl
GO:0008104; P:protein localization; IEA:Ensembl
GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Ensembl
GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl
GO:0001975; P:response to amphetamine; IEA:Ensembl
GO:0042493; P:response to drug; IEA:Ensembl
GO:0045471; P:response to ethanol; IDA:UniProtKB
GO:0009611; P:response to wounding; IEA:Ensembl
GO:0019233; P:sensory perception of pain; IEA:Ensembl
GO:0042428; P:serotonin metabolic process; IEA:Ensembl
GO:0030431; P:sleep; IEA:Ensembl
GO:0001964; P:startle response; IEA:Ensembl
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome
GO:0006810; P:transport; TAS:ProtInc
GO:0008542; P:visual learning; IEA:Ensembl
Interpro
InterPro; IPR001828; ANF_lig-bd_rcpt
InterPro; IPR019594; Glu_rcpt_Glu/Gly-bd
InterPro; IPR001320; Iontro_glu_rcpt
InterPro; IPR001508; NMDA_rcpt
InterPro; IPR018884; NMDAR2_C
InterPro; IPR028082; Peripla_BP_I
InterPro; IPR001638; SBP_bac_3
Pfam
Pfam; PF01094; ANF_receptor;
Pfam; PF00060; Lig_chan;
Pfam; PF10565; NMDAR2_C;
Pfam; PF00497; SBP_bac_3;
SMART
SMART; SM00918; Lig_chan-Glu_bd;
SMART; SM00079; PBPe;
PROSITE
PRINTS
PRINTS; PR00177; NMDARECEPTOR;