LipidDB ID

LipidDB-9606-00118

Entry Name

UniProt Accession

Q9UL25; Q14466; Q569H3;

Theoretical PI

8.11

Molecular Weight

24347.57

Genbank Protein ID

AAF00048.1; AAH21901.1; AAH92475.1; BAA07682.1;

Genbank Nucleotide ID

AF091035; BC021901; BC092475; D42087;

Protein Name

Ras-related protein Rab-21

Protein Synonyms/Alias

Gene Name

RAB21

Gene Synonyms/Alias

KIAA0118;

Created Date

27-APR-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Strader LC, Ritchie S, Soule JD, McGinnis KM, Steber CM. Recessive-interferingmutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpressionof its homologue, SNEEZY. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12771-6. Epub 2004 Aug 12.[PMID:15308775]

Functional Description

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis.

Sequence Annotation

Nucleotide-binding: 26 34 GTP.
Nucleotide-binding: 74 78 GTP.
Nucleotide-binding: 132 135 GTP.
Nucleotide-binding: 162 164 GTP.
Motif: 48 56 Effector region.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 222 222 Cysteine methyl ester.

Protein Length

225 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; IDA:LIFEdb
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;