Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00112
Entry Name
UniProt Accession
Theoretical PI
8.78
Molecular Weight
27368.25
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Rho-related GTP-binding protein RhoE
Protein Synonyms/Alias
Protein MemB; Rho family GTPase 3; Rho-related GTP-binding protein Rho8; Rnd3;
Gene Name
RND3
Gene Synonyms/Alias
ARHE; RHO8; RHOE;
Created Date
24-MAY-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
241
Canonical
RKDKAKSCTVM****
[1]
S-Farnesylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Foster R, Hu KQ, Lu Y, Nolan KM, Thissen J, Settleman J. Identification of anovel human Rho protein with unusual properties: GTPase deficiency and in vivofarnesylation. Mol Cell Biol. 1996 Jun;16(6):2689-99.[PMID:8649376]
Functional Description
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
Sequence Annotation
Nucleotide-binding: 30 37 GTP.
Nucleotide-binding: 77 81 GTP.
Nucleotide-binding: 135 138 GTP.
Motif: 52 60 Effector region.
Modified residue: 241 241 Cysteine methyl ester.
Protein Length
244 AA.
Protein Sequence
(Canonical)
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY  60
TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE  120
IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL  180
QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS  240
CTVM                                                               244
FASTA
(Canonical)
>LipidDB-9606-00112|P61587
MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENY
TASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGE
IQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSAL
QSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKS
CTVM
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; TAS:ProtInc
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc
GO:0007155; P:cell adhesion; TAS:ProtInc
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00174; RHO;
PROSITE
PROSITE; PS51420; RHO;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;