Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00107
Entry Name
UniProt Accession
Theoretical PI
8.64
Molecular Weight
49293.39
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
D(1A) dopamine receptor
Protein Synonyms/Alias
Dopamine D1 receptor;
Gene Name
DRD1
Gene Synonyms/Alias
Created Date
01-MAY-1991
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
347
Canonical
AFSTLLGCYRLCPAT
[1]
S-Palmitoylation
351
Canonical
LLGCYRLCPATNNAI
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Jin H, Xie Z, George SR, O'Dowd BF. Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Eur J Pharmacol. 1999 Dec15;386(2-3):305-12.[PMID:10618483]
Functional Description
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Sequence Annotation
Topological domain: 1 23 Extracellular.
Transmembrane: 24 49 Helical; Name=1.
Topological domain: 50 60 Cytoplasmic.
Transmembrane: 61 87 Helical; Name=2.
Topological domain: 88 96 Extracellular.
Transmembrane: 97 119 Helical; Name=3.
Topological domain: 120 138 Cytoplasmic.
Transmembrane: 139 163 Helical; Name=4.
Topological domain: 164 192 Extracellular.
Transmembrane: 193 218 Helical; Name=5.
Topological domain: 219 272 Cytoplasmic.
Transmembrane: 273 299 Helical; Name=6.
Topological domain: 300 312 Extracellular.
Transmembrane: 313 337 Helical; Name=7.
Topological domain: 338 446 Cytoplasmic.
Protein Length
446 AA.
Protein Sequence
(Canonical)
MRTLNTSAMD GTGLVVERDF SVRILTACFL SLLILSTLLG NTLVCAAVIR FRHLRSKVTN  60
FFVISLAVSD LLVAVLVMPW KAVAEIAGFW PFGSFCNIWV AFDIMCSTAS ILNLCVISVD  120
RYWAISSPFR YERKMTPKAA FILISVAWTL SVLISFIPVQ LSWHKAKPTS PSDGNATSLA  180
ETIDNCDSSL SRTYAISSSV ISFYIPVAIM IVTYTRIYRI AQKQIRRIAA LERAAVHAKN  240
CQTTTGNGKP VECSQPESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI LNCILPFCGS  300
GETQPFCIDS NTFDVFVWFG WANSSLNPII YAFNADFRKA FSTLLGCYRL CPATNNAIET  360
VSINNNGAAM FSSHHEPRGS ISKECNLVYL IPHAVGSSED LKKEEAAGIA RPLEKLSPAL  420
SVILDYDTDV SLEKIQPITQ NGQHPT                                       446
FASTA
(Canonical)
>LipidDB-9606-00107|P21728
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; IC:BHF-UCL
GO:0005634; C:nucleus; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0035240; F:dopamine binding; IMP:BHF-UCL
GO:0004952; F:dopamine neurotransmitter receptor activity; IDA:MGI
GO:0001588; F:dopamine neurotransmitter receptor activity, coupled via Gs; IDA:BHF-UCL
GO:0007190; P:activation of adenylate cyclase activity; IDA:BHF-UCL
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IDA:BHF-UCL
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:UniProtKB
GO:0007628; P:adult walking behavior; ISS:BHF-UCL
GO:0014002; P:astrocyte development; IEA:Ensembl
GO:0001662; P:behavioral fear response; IEA:Ensembl
GO:0048148; P:behavioral response to cocaine; IEA:Ensembl
GO:0071870; P:cellular response to catecholamine stimulus; IDA:BHF-UCL
GO:0021853; P:cerebral cortex GABAergic interneuron migration; ISS:BHF-UCL
GO:0001661; P:conditioned taste aversion; IEA:Ensembl
GO:0021542; P:dentate gyrus development; IEA:Ensembl
GO:0042417; P:dopamine metabolic process; IC:BHF-UCL
GO:0015872; P:dopamine transport; IEA:Ensembl
GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:BHF-UCL
GO:0046323; P:glucose import; IEA:Ensembl
GO:0007625; P:grooming behavior; IEA:Ensembl
GO:0046959; P:habituation; IEA:Ensembl
GO:0060292; P:long term synaptic depression; IEA:Ensembl
GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl
GO:0042711; P:maternal behavior; IEA:Ensembl
GO:0007617; P:mating behavior; ISS:BHF-UCL
GO:0007613; P:memory; IEA:Ensembl
GO:0019228; P:neuronal action potential; IEA:Ensembl
GO:0035106; P:operant conditioning; IEA:Ensembl
GO:0030432; P:peristalsis; IEA:Ensembl
GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IDA:BHF-UCL
GO:0010579; P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0030819; P:positive regulation of cAMP biosynthetic process; IDA:BHF-UCL
GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL
GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IDA:BHF-UCL
GO:0043268; P:positive regulation of potassium ion transport; ISS:BHF-UCL
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL
GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL
GO:0060134; P:prepulse inhibition; ISS:BHF-UCL
GO:0006606; P:protein import into nucleus; IEA:Ensembl
GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl
GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; IC:BHF-UCL
GO:0001975; P:response to amphetamine; IEA:Ensembl
GO:0042493; P:response to drug; ISS:BHF-UCL
GO:0046960; P:sensitization; IEA:Ensembl
GO:0021756; P:striatum development; IEA:Ensembl
GO:0007416; P:synapse assembly; ISS:BHF-UCL
GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl
GO:0001659; P:temperature homeostasis; IEA:Ensembl
GO:0019226; P:transmission of nerve impulse; ISS:BHF-UCL
GO:0042311; P:vasodilation; IEA:InterPro
GO:0008542; P:visual learning; ISS:BHF-UCL
Interpro
InterPro; IPR001413; Dopamine_D1_rcpt
InterPro; IPR000929; Dopamine_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00565; DOPAMINED1AR;
PRINTS; PR00242; DOPAMINER;
PRINTS; PR00237; GPCRRHODOPSN;