Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00103
Entry Name
UniProt Accession
Theoretical PI
5.74
Molecular Weight
202167.16
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Integrin beta-4
Protein Synonyms/Alias
GP150; CD104;
Gene Name
ITGB4
Gene Synonyms/Alias
Created Date
01-APR-1990
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
732
Canonical
LALLLLLCWKYCACC
[1]
S-Palmitoylation
736
Canonical
LLLCWKYCACCKACL
[1]
S-Palmitoylation
738
Canonical
LCWKYCACCKACLAL
[1]
S-Palmitoylation
739
Canonical
CWKYCACCKACLALL
[1]
S-Palmitoylation
742
Canonical
YCACCKACLALLPCC
[1]
S-Palmitoylation
748
Canonical
ACLALLPCCNRGHMV
[1]
S-Palmitoylation
749
Canonical
CLALLPCCNRGHMVG
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, ReshMD, Giancotti FG. Compartmentalization of integrin alpha6beta4 signaling in lipidrafts. J Cell Biol. 2003 Sep 29;162(7):1189-96.[PMID:14517202]
Functional Description
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Sequence Annotation
Topological domain: 28 710 Extracellular.
Transmembrane: 711 733 Helical.
Topological domain: 734 1822 Cytoplasmic.
Domain: 29 73 PSI.
Domain: 131 329 VWFA.
Domain: 979 1084 Calx-beta.
Domain: 1129 1218 Fibronectin type-III 1.
Domain: 1222 1321 Fibronectin type-III 2.
Domain: 1530 1625 Fibronectin type-III 3.
Domain: 1643 1739 Fibronectin type-III 4.
Region: 456 619 Cysteine-rich tandem repeats.
Region: 732 749 Palmitoylated on several cysteines.
Modified residue: 1530 1530 Phosphothreonine.
Protein Length
1822 AA.
Protein Sequence
(Canonical)
MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR  60
CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL  120
EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV  180
PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL  240
QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR  300
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE  360
EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG  420
THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV  480
CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN  540
FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR  600
CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE  660
LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL  720
LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR  780
SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC  840
AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK  900
LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL  960
LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG  1020
KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH  1080
VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS  1140
RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG  1200
AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV  1260
NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP  1320
KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTG CGWKFEPLLG  1380
EELDLRRVTW RLPPELIPRL SASSGRSSDA EAPHGPPDDG GAGGKGGSLP RSATPGPPGE  1440
HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH  1500
SHSTTLPRDY STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY  1560
SVEYQLLNGG ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES  1620
QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM  1680
AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG  1740
PFPQLGSRAG LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF  1800
VSRTLTTSGT LSTHMDQQFF QT                                           1822
FASTA
(Canonical)
>LipidDB-9606-00103|P16144
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRR
CNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFEL
EVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAIL
QTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYR
TQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDG
THVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCV
CSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGR
CHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDE
LKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLL
LLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLR
SGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTREC
AQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLK
LTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQL
LVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGG
KSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFH
VQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGS
RKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYG
AQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLV
NDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQP
KRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLG
EELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGE
HLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEH
SHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGY
SVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIES
QVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEM
AQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGG
PFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEF
VSRTLTTSGTLSTHMDQQFFQT
Gene Ontology
GO:0009925; C:basal plasma membrane; IEA:Ensembl
GO:0005604; C:basement membrane; IEA:Ensembl
GO:0031252; C:cell leading edge; IDA:UniProtKB
GO:0009986; C:cell surface; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0030056; C:hemidesmosome; IDA:UniProtKB
GO:0008305; C:integrin complex; TAS:ProtInc
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0043235; C:receptor complex; IDA:MGI
GO:0001664; F:G-protein coupled receptor binding; IPI:UniProtKB
GO:0004872; F:receptor activity; IEA:InterPro
GO:0097186; P:amelogenesis; IMP:UniProtKB
GO:0006914; P:autophagy; IMP:UniProt
GO:0007155; P:cell adhesion; NAS:ProtInc
GO:0034329; P:cell junction assembly; TAS:Reactome
GO:0048870; P:cell motility; IMP:UniProtKB
GO:0007160; P:cell-matrix adhesion; IMP:UniProtKB
GO:0048565; P:digestive tract development; IMP:UniProtKB
GO:0030198; P:extracellular matrix organization; TAS:Reactome
GO:0046847; P:filopodium assembly; IEA:Ensembl
GO:0031581; P:hemidesmosome assembly; IDA:UniProtKB
GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW
GO:0048333; P:mesodermal cell differentiation; IEP:UniProtKB
GO:0035878; P:nail development; IMP:UniProtKB
GO:0072001; P:renal system development; IMP:UniProtKB
GO:0009611; P:response to wounding; IDA:UniProtKB
GO:0043588; P:skin development; IMP:UniProtKB
Interpro
InterPro; IPR003644; Calx_beta
InterPro; IPR013032; EGF-like_CS
InterPro; IPR013111; EGF_extracell
InterPro; IPR003961; Fibronectin_type3
InterPro; IPR013783; Ig-like_fold
InterPro; IPR015812; Integrin_bsu
InterPro; IPR012013; Integrin_bsu-4
InterPro; IPR002369; Integrin_bsu_N
InterPro; IPR012896; Integrin_bsu_tail
InterPro; IPR016201; Plexin-like_fold
InterPro; IPR002035; VWF_A
Pfam
Pfam; PF03160; Calx-beta;
Pfam; PF07974; EGF_2;
Pfam; PF00041; fn3;
Pfam; PF07965; Integrin_B_tail;
Pfam; PF00362; Integrin_beta;
SMART
SMART; SM00237; Calx_beta;
SMART; SM00060; FN3;
SMART; SM00187; INB;
SMART; SM00423; PSI;
SMART; SM00327; VWA;
PROSITE
PROSITE; PS00022; EGF_1;
PROSITE; PS01186; EGF_2;
PROSITE; PS50853; FN3;
PROSITE; PS00243; INTEGRIN_BETA;
PRINTS
PRINTS; PR01186; INTEGRINB;