Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00083
Entry Name
UniProt Accession
Theoretical PI
8.23
Molecular Weight
49469.38
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Monocarboxylate transporter 4
Protein Synonyms/Alias
MCT 4; Solute carrier family 16 member 3;
Gene Name
SLC16A3
Gene Synonyms/Alias
MCT4;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
190
Canonical
LGGLLLNCCVCAALM
[1]
S-Palmitoylation
191
Canonical
GGLLLNCCVCAALMR
[1]
S-Palmitoylation
409
Canonical
LLLGNFFCIRKKPKE
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Sequence Annotation
Topological domain: 2 17 Cytoplasmic.
Transmembrane: 18 38 Helical.
Topological domain: 39 61 Extracellular.
Transmembrane: 62 82 Helical.
Topological domain: 83 84 Cytoplasmic.
Transmembrane: 85 105 Helical.
Topological domain: 106 109 Extracellular.
Transmembrane: 110 130 Helical.
Topological domain: 131 149 Cytoplasmic.
Transmembrane: 150 170 Helical.
Topological domain: 171 179 Extracellular.
Transmembrane: 180 200 Helical.
Topological domain: 201 227 Cytoplasmic.
Transmembrane: 228 248 Helical.
Topological domain: 249 264 Extracellular.
Transmembrane: 265 285 Helical.
Topological domain: 286 294 Cytoplasmic.
Transmembrane: 295 315 Helical.
Topological domain: 316 317 Extracellular.
Transmembrane: 318 338 Helical.
Topological domain: 339 351 Cytoplasmic.
Transmembrane: 352 372 Helical.
Topological domain: 373 384 Extracellular.
Transmembrane: 385 405 Helical.
Topological domain: 406 465 Cytoplasmic.
Modified residue: 460 460 Phosphothreonine.
Modified residue: 464 464 Phosphoserine.
Protein Length
465 AA.
Protein Sequence
(Canonical)
MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT  60
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV  120
ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF  180
LILGGLLLNC CVCAALMRPL VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL  240
GLFVPPVFVV SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF  300
SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL  360
LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE  420
VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEVVHT PETSV                  465
FASTA
(Canonical)
>LipidDB-9606-00083|O15427
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Gene Ontology
GO:0015629; C:actin cytoskeleton; IDA:HPA
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0016020; C:membrane; TAS:ProtInc
GO:0031965; C:nuclear membrane; IDA:HPA
GO:0005886; C:plasma membrane; IDA:HPA
GO:0008028; F:monocarboxylic acid transmembrane transporter activity; TAS:ProtInc
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB
GO:0015355; F:secondary active monocarboxylate transmembrane transporter activity; IEA:InterPro
GO:0015293; F:symporter activity; IEA:UniProtKB-KW
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0044237; P:cellular metabolic process; TAS:Reactome
GO:0050900; P:leukocyte migration; TAS:Reactome
GO:0015718; P:monocarboxylic acid transport; TAS:ProtInc
GO:0006090; P:pyruvate metabolic process; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome
Interpro
InterPro; IPR011701; MFS
InterPro; IPR020846; MFS_dom
InterPro; IPR016196; MFS_dom_general_subst_transpt
InterPro; IPR004743; Monocarb_transpt
Pfam
Pfam; PF07690; MFS_1;
SMART
PROSITE
PROSITE; PS50850; MFS;
PRINTS