Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00082
Entry Name
UniProt Accession
Theoretical PI
8.53
Molecular Weight
19746.11
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Betacellulin
Protein Synonyms/Alias
BTC;
Gene Name
BTC
Gene Synonyms/Alias
Created Date
01-FEB-1994
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
139
Canonical
IILVIGVCTCCHPLR
[1]
S-Palmitoylation
141
Canonical
LVIGVCTCCHPLRKR
[1]
S-Palmitoylation
142
Canonical
VIGVCTCCHPLRKRR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Stoeck A, Shang L, Dempsey PJ. Sequential and gamma-secretase-dependentprocessing of the betacellulin precursor generates a palmitoylatedintracellular-domain fragment that inhibits cell growth. J Cell Sci. 2010 Jul1;123(Pt 13):2319-31. doi: 10.1242/jcs.060830. Epub 2010 Jun 8.[PMID:20530572]
Functional Description
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Sequence Annotation
Topological domain: 32 118 Extracellular.
Transmembrane: 119 139 Helical.
Topological domain: 140 178 Cytoplasmic.
Domain: 65 105 EGF-like.
Protein Length
178 AA.
Protein Sequence
(Canonical)
MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS  60
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL  120
VICLIAVMVV FIILVIGVCT CCHPLRKRRK RKKKEEEMET LGKDITPINE DIEETNIA    178
FASTA
(Canonical)
>LipidDB-9606-00082|P35070
MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
Gene Ontology
GO:0005576; C:extracellular region; TAS:Reactome
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005154; F:epidermal growth factor receptor binding; TAS:ProtInc
GO:0008083; F:growth factor activity; TAS:ProtInc
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome
GO:0045087; P:innate immune response; TAS:Reactome
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome
GO:0045597; P:positive regulation of cell differentiation; IEA:Ensembl
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW
GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc
GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl
GO:0045840; P:positive regulation of mitosis; IEA:Ensembl
GO:0035810; P:positive regulation of urine volume; IEA:Ensembl
Interpro
InterPro; IPR000742; EG-like_dom
InterPro; IPR013032; EGF-like_CS
InterPro; IPR015497; EGF_rcpt_ligand
Pfam
SMART
SMART; SM00181; EGF;
PROSITE
PROSITE; PS00022; EGF_1;
PROSITE; PS01186; EGF_2;
PROSITE; PS50026; EGF_3;
PRINTS