Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00076
Entry Name
UniProt Accession
Theoretical PI
8.75
Molecular Weight
93885.56
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
ATP-binding cassette sub-family B member 6, mitochondrial
Protein Synonyms/Alias
Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter;
Gene Name
ABCB6
Gene Synonyms/Alias
MTABC3; PRP; UMAT;
Created Date
21-FEB-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
50
Canonical
ALVLALPCRRRERPA
[1]
S-Palmitoylation
268
Canonical
LQLVVLICLGLMGLE
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
Sequence Annotation
Transmembrane: 27 47 Helical.
Transmembrane: 73 93 Helical.
Transmembrane: 107 127 Helical.
Transmembrane: 148 168 Helical.
Transmembrane: 186 206 Helical.
Transmembrane: 265 285 Helical.
Transmembrane: 376 396 Helical.
Transmembrane: 409 431 Helical.
Transmembrane: 502 522 Helical.
Transmembrane: 530 550 Helical.
Domain: 265 556 ABC transmembrane type-1.
Domain: 590 824 ABC transporter.
Nucleotide-binding: 623 634 ATP.
Binding site: 599 599 ATP.
Protein Length
842 AA.
Protein Sequence
(Canonical)
MVTVGNYCEA EGPVGPAWMQ DGLSPCFFFT LVPSTRMALG TLALVLALPC RRRERPAGAD  60
SLSWGAGPRI SPYVLQLLLA TLQAALPLAG LAGRVGTARG APLPSYLLLA SVLESLAGAC  120
GLWLLVVERS QARQRLAMGI WIKFRHSPGL LLLWTVAFAA ENLALVSWNS PQWWWARADL  180
GQQVQFSLWV LRYVVSGGLF VLGLWAPGLR PQSYTLQVHE EDQDVERSQV RSAAQQSTWR  240
DFGRKLRLLS GYLWPRGSPA LQLVVLICLG LMGLERALNV LVPIFYRNIV NLLTEKAPWN  300
SLAWTVTSYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRRVELLIF SHLHELSLRW  360
HLGRRTGEVL RIADRGTSSV TGLLSYLVFN VIPTLADIII GIIYFSMFFN AWFGLIVFLC  420
MSLYLTLTIV VTEWRTKFRR AMNTQENATR ARAVDSLLNF ETVKYYNAES YEVERYREAI  480
IKYQGLEWKS SASLVLLNQT QNLVIGLGLL AGSLLCAYFV TEQKLQVGDY VLFGTYIIQL  540
YMPLNWFGTY YRMIQTNFID MENMFDLLKE ETEVKDLPGA GPLRFQKGRI EFENVHFSYA  600
DGRETLQDVS FTVMPGQTLA LVGPSGAGKS TILRLLFRFY DISSGCIRID GQDISQVTQA  660
SLRSHIGVVP QDTVLFNDTI ADNIRYGRVT AGNDEVEAAA QAAGIHDAIM AFPEGYRTQV  720
GERGLKLSGG EKQRVAIART ILKAPGIILL DEATSALDTS NERAIQASLA KVCANRTTIV  780
VAHRLSTVVN ADQILVIKDG CIVERGRHEA LLSRGGVYAD MWQLQQGQEE TSEDTKPQTM  840
ER                                                                 842
FASTA
(Canonical)
>LipidDB-9606-00076|Q9NP58
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGAD
SLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGAC
GLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADL
GQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWR
DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWN
SLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRW
HLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLC
MSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAI
IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQL
YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYA
DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQA
SLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV
GERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIV
VAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTM
ER
Gene Ontology
GO:0043190; C:ATP-binding cassette (ABC) transporter complex; NAS:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005768; C:endosome; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0031307; C:integral component of mitochondrial outer membrane; IDA:UniProtKB
GO:0005740; C:mitochondrial envelope; IDA:MGI
GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB
GO:0005739; C:mitochondrion; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005524; F:ATP binding; IDA:MGI
GO:0015562; F:efflux transmembrane transporter activity; IDA:UniProtKB
GO:0020037; F:heme binding; IDA:UniProtKB
GO:0015232; F:heme transporter activity; TAS:Reactome
GO:0015439; F:heme-transporting ATPase activity; IMP:UniProtKB
GO:0007420; P:brain development; IMP:UniProtKB
GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB
GO:0015886; P:heme transport; IDA:UniProtKB
GO:0006779; P:porphyrin-containing compound biosynthetic process; IDA:UniProtKB
GO:0043588; P:skin development; IMP:UniProtKB
GO:0055085; P:transmembrane transport; IBA:RefGenome
GO:0006810; P:transport; IDA:MGI
Interpro
InterPro; IPR003593; AAA+_ATPase
InterPro; IPR011527; ABC1_TM_dom
InterPro; IPR003439; ABC_transporter-like
InterPro; IPR017871; ABC_transporter_CS
InterPro; IPR001140; ABC_transptr_TM_dom
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00664; ABC_membrane;
Pfam; PF00005; ABC_tran;
SMART
SMART; SM00382; AAA;
PROSITE
PROSITE; PS50929; ABC_TM1F;
PROSITE; PS00211; ABC_TRANSPORTER_1;
PROSITE; PS50893; ABC_TRANSPORTER_2;
PRINTS