LipidDB ID

LipidDB-9606-00061

Entry Name

UniProt Accession

P62491; B2R4B6; B4DT13; P24410; Q5TZN9; Q9JLX1;

Theoretical PI

6.12

Molecular Weight

24393.52

Genbank Protein ID

CAA37300.1; CAA40064.1; AAC32887.1; AAM21094.1; CAG28597.1; CAG38732.1; AAV38953.1; AAV38956.1; BAG61825.1; BAG34713.1; EAW77752.1; AAH13348.1;

Genbank Nucleotide ID

X53143; X56740; AF000231; AF498946; CR407669; CR536493; BT020151; BT020154; AK300008; AK311770; AC011939; AC084854; CH471082; BC013348;

Protein Name

Ras-related protein Rab-11A

Protein Synonyms/Alias

Rab-11; YL8;

Gene Name

RAB11A

Gene Synonyms/Alias

RAB11;

Created Date

19-JUL-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Joberty G, Tavitian A, Zahraoui A. Isoprenylation of Rab proteins possessing aC-terminal CaaX motif. FEBS Lett. 1993 Sep 20;330(3):323-8.[PMID:8375503]
[2] Gromov P, Celis JE. Rab11a is modified in vivo by isoprenoid geranylgeranyl.Electrophoresis. 1998 Jul;19(10):1803-7.[PMID:9719562]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Sequence Annotation

Nucleotide-binding: 18 26 GTP.
Nucleotide-binding: 66 70 GTP.
Nucleotide-binding: 124 127 GTP.
Nucleotide-binding: 154 156 GTP.
Motif: 40 48 Effector region.
Modified residue: 2 2 N-acetylglycine.
Modified residue: 213 213 Cysteine methyl ester.

Protein Length

216 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IEA:Ensembl
GO:0032154; C:cleavage furrow; IDA:UniProtKB
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005771; C:multivesicular body; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0045335; C:phagocytic vesicle; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0043234; C:protein complex; IDA:UniProtKB
GO:0055037; C:recycling endosome; ISS:UniProtKB
GO:0005802; C:trans-Golgi network; IDA:MGI
GO:0030133; C:transport vesicle; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0031489; F:myosin V binding; IPI:UniProtKB
GO:0019905; F:syntaxin binding; NAS:UniProtKB
GO:0000910; P:cytokinesis; IMP:UniProtKB
GO:0090150; P:establishment of protein localization to membrane; IMP:UniProtKB
GO:1990182; P:exosomal secretion; IMP:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0032402; P:melanosome transport; ISS:UniProtKB
GO:0036258; P:multivesicular body assembly; IMP:UniProtKB
GO:0031175; P:neuron projection development; IMP:UniProtKB
GO:0048227; P:plasma membrane to endosome transport; NAS:UniProtKB
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl
GO:0072659; P:protein localization to plasma membrane; IDA:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0010796; P:regulation of multivesicular body size; IMP:UniProtKB
GO:0051223; P:regulation of protein transport; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0055085; P:transmembrane transport; TAS:Reactome
GO:0016192; P:vesicle-mediated transport; IDA:UniProtKB
GO:0006833; P:water transport; TAS:Reactome

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;