Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00060
Entry Name
UniProt Accession
Theoretical PI
9.35
Molecular Weight
10441.16
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Phospholemman
Protein Synonyms/Alias
FXYD domain-containing ion transport regulator 1;
Gene Name
FXYD1
Gene Synonyms/Alias
PLM;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
60
Canonical
LIVLSRRCRCKFNQQ
[1]
S-Palmitoylation
62
Canonical
VLSRRCRCKFNQQQR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Tulloch LB, Howie J, Wypijewski KJ, Wilson CR, Bernard WG, Shattock MJ, FullerW. The inhibitory effect of phospholemman on the sodium pump requires itspalmitoylation. J Biol Chem. 2011 Oct 14;286(41):36020-31. doi:10.1074/jbc.M111.282145. Epub 2011 Aug 25.[PMID:21868384]
Functional Description
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Sequence Annotation
Topological domain: 21 35 Extracellular.
Transmembrane: 36 56 Helical.
Topological domain: 57 92 Cytoplasmic.
Modified residue: 79 79 Phosphothreonine.
Modified residue: 83 83 Phosphoserine; by PKA and PKC.
Modified residue: 88 88 Phosphoserine; by PKA.
Protein Length
92 AA.
Protein Sequence
(Canonical)
MASLGHILVF CVGLLTMAKA ESPKEHDPFT YDYQSLQIGG LVIAGILFIL GILIVLSRRC  60
RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR                                92
FASTA
(Canonical)
>LipidDB-9606-00060|O00168
MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC
RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
Gene Ontology
GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0042383; C:sarcolemma; ISS:BHF-UCL
GO:0005890; C:sodium:potassium-exchanging ATPase complex; ISS:BHF-UCL
GO:0005254; F:chloride channel activity; TAS:ProtInc
GO:0044325; F:ion channel binding; ISS:BHF-UCL
GO:0017080; F:sodium channel regulator activity; ISS:BHF-UCL
GO:1902476; P:chloride transmembrane transport; TAS:GOC
GO:0006821; P:chloride transport; TAS:ProtInc
GO:0034220; P:ion transmembrane transport; TAS:Reactome
GO:0006936; P:muscle contraction; TAS:ProtInc
GO:1903278; P:positive regulation of sodium ion export from cell; ISS:BHF-UCL
GO:0086036; P:regulation of cardiac muscle cell membrane potential; ISS:BHF-UCL
GO:0008016; P:regulation of heart contraction; TAS:BHF-UCL
GO:2000649; P:regulation of sodium ion transmembrane transporter activity; ISS:BHF-UCL
GO:0055085; P:transmembrane transport; TAS:Reactome
Interpro
InterPro; IPR000272; Ion-transport_regulator_FXYD
Pfam
Pfam; PF02038; ATP1G1_PLM_MAT8;
SMART
PROSITE
PROSITE; PS01310; FXYD;
PRINTS