Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00046
Entry Name
UniProt Accession
Theoretical PI
5.41
Molecular Weight
29815.53
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Syntaxin-7
Protein Synonyms/Alias
Gene Name
STX7
Gene Synonyms/Alias
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
239
Canonical
RKSRKTLCIIILILV
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] He Y, Linder ME. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. J Lipid Res. 2009 Mar;50(3):398-404. doi:10.1194/jlr.M800360-JLR200. Epub 2008 Oct 31.[PMID:18980942]
Functional Description
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
Sequence Annotation
Topological domain: 2 238 Cytoplasmic.
Transmembrane: 239 259 Helical; Anchor for type IV membraneprotein.
Topological domain: 260 261 Vesicular.
Domain: 165 227 t-SNARE coiled-coil homology.
Modified residue: 2 2 N-acetylserine.
Modified residue: 45 45 Phosphoserine.
Modified residue: 79 79 Phosphothreonine.
Modified residue: 125 125 Phosphoserine.
Modified residue: 126 126 Phosphoserine.
Modified residue: 129 129 Phosphoserine.
Modified residue: 205 205 Phosphoserine.
Protein Length
261 AA.
Protein Sequence
(Canonical)
MSYTPGVGGD PAQLAQRISS NIQKITQCSV EIQRTLNQLG TPQDSPELRQ QLQQKQQYTN  60
QLAKETDKYI KEFGSLPTTP SEQRQRKIQK DRLVAEFTTS LTNFQKVQRQ AAEREKEFVA  120
RVRASSRVSG SFPEDSSKER NLVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA  180
DIMDINEIFK DLGMMIHEQG DVIDSIEANV ENAEVHVQQA NQQLSRAADY QRKSRKTLCI  240
IILILVIGVA IISLIIWGLN H                                            261
FASTA
(Canonical)
>LipidDB-9606-00046|O15400
MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTN
QLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVA
RVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEA
DIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCI
IILILVIGVAIISLIIWGLNH
Gene Ontology
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0031201; C:SNARE complex; IBA:RefGenome
GO:0005484; F:SNAP receptor activity; IBA:RefGenome
GO:0000149; F:SNARE binding; IDA:MGI
GO:0006886; P:intracellular protein transport; IBA:RefGenome
GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:ProtInc
GO:0016079; P:synaptic vesicle exocytosis; IBA:RefGenome
Interpro
InterPro; IPR006012; Syntaxin/epimorphin_CS
InterPro; IPR006011; Syntaxin_N
InterPro; IPR010989; t-SNARE
InterPro; IPR000727; T_SNARE_dom
Pfam
Pfam; PF05739; SNARE;
SMART
SMART; SM00503; SynN;
SMART; SM00397; t_SNARE;
PROSITE
PROSITE; PS00914; SYNTAXIN;
PROSITE; PS50192; T_SNARE;
PRINTS