Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00044
Entry Name
UniProt Accession
Theoretical PI
5.81
Molecular Weight
347603.3
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Huntingtin
Protein Synonyms/Alias
Huntington disease protein; HD protein;
Gene Name
HTT
Gene Synonyms/Alias
HD; IT15;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
212
Canonical
YLVNLLPCLTRTSKR
[1][2]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC,Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, RubinszteinDC, El-Husseini A, Hayden MR. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci. 2006 Jun;9(6):824-31. Epub 2006May 14.[PMID:16699508]
[2] Truant R, Atwal R, Burtnik A. Hypothesis: Huntingtin may function in membrane association and vesicular trafficking. Biochem Cell Biol. 2006 Dec;84(6):912-7.Review.[PMID:17215878]
Functional Description
May play a role in microtubule-mediated transport or vesicle function.
Sequence Annotation
Region: 3 13 Sufficient for interaction with TPR.
Motif: 2395 2404 Nuclear export signal.
Functional site: 511 512 Cleavage; by apopain.
Functional site: 528 529 Cleavage; by apopain.
Functional site: 550 551 Cleavage; by apopain.
Functional site: 587 588 Cleavage; by apopain.
Modified residue: 9 9 N6-acetyllysine.
Modified residue: 176 176 N6-acetyllysine.
Modified residue: 234 234 N6-acetyllysine.
Modified residue: 343 343 N6-acetyllysine.
Modified residue: 411 411 Phosphoserine.
Modified residue: 432 432 Phosphoserine.
Modified residue: 442 442 N6-acetyllysine.
Modified residue: 1179 1179 Phosphoserine; by CDK5.
Modified residue: 1199 1199 Phosphoserine; by CDK5.
Modified residue: 1870 1870 Phosphoserine.
Modified residue: 1874 1874 Phosphoserine.
Protein Length
3142 AA.
Protein Sequence
(Canonical)
MATLEKLMKA FESLKSFQQQ QQQQQQQQQQ QQQQQQQQPP PPPPPPPPPQ LPQPPPQAQP  60
LLPQPQPPPP PPPPPPGPAV AEEPLHRPKK ELSATKKDRV NHCLTICENI VAQSVRNSPE  120
FQKLLGIAME LFLLCSDDAE SDVRMVADEC LNKVIKALMD SNLPRLQLEL YKEIKKNGAP  180
RSLRAALWRF AELAHLVRPQ KCRPYLVNLL PCLTRTSKRP EESVQETLAA AVPKIMASFG  240
NFANDNEIKV LLKAFIANLK SSSPTIRRTA AGSAVSICQH SRRTQYFYSW LLNVLLGLLV  300
PVEDEHSTLL ILGVLLTLRY LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS AEQLVQVYEL  360
TLHHTQHQDH NVVTGALELL QQLFRTPPPE LLQTLTAVGG IGQLTAAKEE SGGRSRSGSI  420
VELIAGGGSS CSPVLSRKQK GKVLLGEEEA LEDDSESRSD VSSSALTASV KDEISGELAA  480
SSGVSTPGSA GHDIITEQPR SQHTLQADSV DLASCDLTSS ATDGDEEDIL SHSSSQVSAV  540
PSDPAMDLND GTQASSPISD SSQTTTEGPD SAVTPSDSSE IVLDGTDNQY LGLQIGQPQD  600
EDEEATGILP DEASEAFRNS SMALQQAHLL KNMSHCRQPS DSSVDKFVLR DEATEPGDQE  660
NKPCRIKGDI GQSTDDDSAP LVHCVRLLSA SFLLTGGKNV LVPDRDVRVS VKALALSCVG  720
AAVALHPESF FSKLYKVPLD TTEYPEEQYV SDILNYIDHG DPQVRGATAI LCGTLICSIL  780
SRSRFHVGDW MGTIRTLTGN TFSLADCIPL LRKTLKDESS VTCKLACTAV RNCVMSLCSS  840
SYSELGLQLI IDVLTLRNSS YWLVRTELLE TLAEIDFRLV SFLEAKAENL HRGAHHYTGL  900
LKLQERVLNN VVIHLLGDED PRVRHVAAAS LIRLVPKLFY KCDQGQADPV VAVARDQSSV  960
YLKLLMHETQ PPSHFSVSTI TRIYRGYNLL PSITDVTMEN NLSRVIAAVS HELITSTTRA  1020
LTFGCCEALC LLSTAFPVCI WSLGWHCGVP PLSASDESRK SCTVGMATMI LTLLSSAWFP  1080
LDLSAHQDAL ILAGNLLAAS APKSLRSSWA SEEEANPAAT KQEEVWPALG DRALVPMVEQ  1140
LFSHLLKVIN ICAHVLDDVA PGPAIKAALP SLTNPPSLSP IRRKGKEKEP GEQASVPLSP  1200
KKGSEASAAS RQSDTSGPVT TSKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST  1260
EKFGGFLRSA LDVLSQILEL ATLQDIGKCV EEILGYLKSC FSREPMMATV CVQQLLKTLF  1320
GTNLASQFDG LSSNPSKSQG RAQRLGSSSV RPGLYHYCFM APYTHFTQAL ADASLRNMVQ  1380
AEQENDTSGW FDVLQKVSTQ LKTNLTSVTK NRADKNAIHN HIRLFEPLVI KALKQYTTTT  1440
CVQLQKQVLD LLAQLVQLRV NYCLLDSDQV FIGFVLKQFE YIEVGQFRES EAIIPNIFFF  1500
LVLLSYERYH SKQIIGIPKI IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGTNKADA  1560
GKELETQKEV VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE DKWKRLSRQI ADIILPMLAK  1620
QQMHIDSHEA LGVLNTLFEI LAPSSLRPVD MLLRSMFVTP NTMASVSTVQ LWISGILAIL  1680
RVLISQSTED IVLSRIQELS FSPYLISCTV INRLRDGDST STLEEHSEGK QIKNLPEETF  1740
SRFLLQLVGI LLEDIVTKQL KVEMSEQQHT FYCQELGTLL MCLIHIFKSG MFRRITAAAT  1800
RLFRSDGCGG SFYTLDSLNL RARSMITTHP ALVLLWCQIL LLVNHTDYRW WAEVQQTPKR  1860
HSLSSTKLLS PQMSGEEEDS DLAAKLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI  1920
VNHIQDLISL SHEPPVQDFI SAVHRNSAAS GLFIQAIQSR CENLSTPTML KKTLQCLEGI  1980
HLSQSGAVLT LYVDRLLCTP FRVLARMVDI LACRRVEMLL AANLQSSMAQ LPMEELNRIQ  2040
EYLQSSGLAQ RHQRLYSLLD RFRLSTMQDS LSPSPPVSSH PLDGDGHVSL ETVSPDKDWY  2100
VHLVKSQCWT RSDSALLEGA ELVNRIPAED MNAFMMNSEF NLSLLAPCLS LGMSEISGGQ  2160
KSALFEAARE VTLARVSGTV QQLPAVHHVF QPELPAEPAA YWSKLNDLFG DAALYQSLPT  2220
LARALAQYLV VVSKLPSHLH LPPEKEKDIV KFVVATLEAL SWHLIHEQIP LSLDLQAGLD  2280
CCCLALQLPG LWSVVSSTEF VTHACSLIYC VHFILEAVAV QPGEQLLSPE RRTNTPKAIS  2340
EEEEEVDPNT QNPKYITAAC EMVAEMVESL QSVLALGHKR NSGVPAFLTP LLRNIIISLA  2400
RLPLVNSYTR VPPLVWKLGW SPKPGGDFGT AFPEIPVEFL QEKEVFKEFI YRINTLGWTS  2460
RTQFEETWAT LLGVLVTQPL VMEQEESPPE EDTERTQINV LAVQAITSLV LSAMTVPVAG  2520
NPAVSCLEQQ PRNKPLKALD TRFGRKLSII RGIVEQEIQA MVSKRENIAT HHLYQAWDPV  2580
PSLSPATTGA LISHEKLLLQ INPERELGSM SYKLGQVSIH SVWLGNSITP LREEEWDEEE  2640
EEEADAPAPS SPPTSPVNSR KHRAGVDIHS CSQFLLELYS RWILPSSSAR RTPAILISEV  2700
VRSLLVVSDL FTERNQFELM YVTLTELRRV HPSEDEILAQ YLVPATCKAA AVLGMDKAVA  2760
EPVSRLLEST LRSSHLPSRV GALHGVLYVL ECDLLDDTAK QLIPVISDYL LSNLKGIAHC  2820
VNIHSQQHVL VMCATAFYLI ENYPLDVGPE FSASIIQMCG VMLSGSEEST PSIIYHCALR  2880
GLERLLLSEQ LSRLDAESLV KLSVDRVNVH SPHRAMAALG LMLTCMYTGK EKVSPGRTSD  2940
PNPAAPDSES VIVAMERVSV LFDRIRKGFP CEARVVARIL PQFLDDFFPP QDIMNKVIGE  3000
FLSNQQPYPQ FMATVVYKVF QTLHSTGQSS MVRDWVMLSL SNFTQRAPVA MATWSLSCFF  3060
VSASTSPWVA AILPHVISRM GKLEQVDVNL FCLVATDFYR HQIEEELDRR AFQSVLEVVA  3120
APGSPYHRLL TCLRNVHKVT TC                                           3142
FASTA
(Canonical)
>LipidDB-9606-00044|P42858
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQP
LLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPE
FQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAP
RSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFG
NFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLV
PVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL
TLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSI
VELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAA
SSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAV
PSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQD
EDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQE
NKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVG
AAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSIL
SRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSS
SYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGL
LKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSV
YLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRA
LTFGCCEALCLLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFP
LDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDRALVPMVEQ
LFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSP
KKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNST
EKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLF
GTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQ
AEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTT
CVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFF
LVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADA
GKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAK
QQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAIL
RVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGKQIKNLPEETF
SRFLLQLVGILLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAAT
RLFRSDGCGGSFYTLDSLNLRARSMITTHPALVLLWCQILLLVNHTDYRWWAEVQQTPKR
HSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLI
VNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCENLSTPTMLKKTLQCLEGI
HLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRVEMLLAANLQSSMAQLPMEELNRIQ
EYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPSPPVSSHPLDGDGHVSLETVSPDKDWY
VHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLAPCLSLGMSEISGGQ
KSALFEAAREVTLARVSGTVQQLPAVHHVFQPELPAEPAAYWSKLNDLFGDAALYQSLPT
LARALAQYLVVVSKLPSHLHLPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLD
CCCLALQLPGLWSVVSSTEFVTHACSLIYCVHFILEAVAVQPGEQLLSPERRTNTPKAIS
EEEEEVDPNTQNPKYITAACEMVAEMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLA
RLPLVNSYTRVPPLVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTS
RTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAG
NPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPV
PSLSPATTGALISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEE
EEEADAPAPSSPPTSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEV
VRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVA
EPVSRLLESTLRSSHLPSRVGALHGVLYVLECDLLDDTAKQLIPVISDYLLSNLKGIAHC
VNIHSQQHVLVMCATAFYLIENYPLDVGPEFSASIIQMCGVMLSGSEESTPSIIYHCALR
GLERLLLSEQLSRLDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKVSPGRTSD
PNPAAPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGE
FLSNQQPYPQFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFF
VSASTSPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEELDRRAFQSVLEVVA
APGSPYHRLLTCLRNVHKVTTC
Gene Ontology
GO:0005776; C:autophagic vacuole; IDA:UniProtKB
GO:0030424; C:axon; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0030659; C:cytoplasmic vesicle membrane; IDA:UniProtKB
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0030425; C:dendrite; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0016234; C:inclusion body; IEA:Ensembl
GO:0005770; C:late endosome; IDA:UniProtKB
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0043234; C:protein complex; IDA:UniProtKB
GO:0048487; F:beta-tubulin binding; IDA:UniProtKB
GO:0050809; F:diazepam binding; IEA:Ensembl
GO:0034452; F:dynactin binding; IPI:UniProtKB
GO:0045505; F:dynein intermediate chain binding; IDA:UniProtKB
GO:0042802; F:identical protein binding; IPI:IntAct
GO:0044325; F:ion channel binding; IDA:UniProtKB
GO:0002039; F:p53 binding; IPI:UniProtKB
GO:0008134; F:transcription factor binding; IBA:RefGenome
GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl
GO:0008088; P:axon cargo transport; IEA:Ensembl
GO:0007569; P:cell aging; IEA:Ensembl
GO:0000052; P:citrulline metabolic process; IEA:Ensembl
GO:0008340; P:determination of adult lifespan; IEA:Ensembl
GO:0007212; P:dopamine receptor signaling pathway; IEA:Ensembl
GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl
GO:0016197; P:endosomal transport; IEA:Ensembl
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Ensembl
GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB
GO:0007030; P:Golgi organization; IMP:UniProtKB
GO:0007625; P:grooming behavior; IEA:Ensembl
GO:0042445; P:hormone metabolic process; IEA:Ensembl
GO:0030073; P:insulin secretion; IEA:Ensembl
GO:0055072; P:iron ion homeostasis; IEA:Ensembl
GO:0051938; P:L-glutamate import; IEA:Ensembl
GO:0019244; P:lactate biosynthetic process from pyruvate; IEA:Ensembl
GO:0007626; P:locomotory behavior; IEA:Ensembl
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0021990; P:neural plate formation; IEA:Ensembl
GO:0051402; P:neuron apoptotic process; IEA:Ensembl
GO:0048666; P:neuron development; IEA:Ensembl
GO:0021988; P:olfactory lobe development; IEA:Ensembl
GO:0048513; P:organ development; IBA:RefGenome
GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl
GO:0031587; P:positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IDA:UniProtKB
GO:0006606; P:protein import into nucleus; IEA:Ensembl
GO:0019805; P:quinolinate biosynthetic process; IEA:Ensembl
GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Ensembl
GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl
GO:0034047; P:regulation of protein phosphatase type 2A activity; IMP:dictyBase
GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl
GO:0051592; P:response to calcium ion; IEA:Ensembl
GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IMP:UniProtKB
GO:0035176; P:social behavior; IEA:Ensembl
GO:0007283; P:spermatogenesis; IEA:Ensembl
GO:0021756; P:striatum development; IEA:Ensembl
GO:0000050; P:urea cycle; IEA:Ensembl
GO:0047496; P:vesicle transport along microtubule; IMP:UniProtKB
GO:0008542; P:visual learning; IEA:Ensembl
Interpro
InterPro; IPR011989; ARM-like
InterPro; IPR016024; ARM-type_fold
InterPro; IPR000091; Huntingtin
InterPro; IPR028426; Huntingtin_fam
InterPro; IPR024613; Huntingtin_middle-repeat
Pfam
Pfam; PF12372; DUF3652;
SMART
PROSITE
PRINTS
PRINTS; PR00375; HUNTINGTIN;