Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00040
Entry Name
UniProt Accession
Theoretical PI
4.64
Molecular Weight
24802.67
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neuromodulin
Protein Synonyms/Alias
Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46;
Gene Name
GAP43
Gene Synonyms/Alias
Created Date
01-AUG-1990
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
3
Canonical
*****MLCCMRRTKQ
[1][2]
S-Palmitoylation
4
Canonical
****MLCCMRRTKQV
[1][2]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Liu Y, Fisher DA, Storm DR. Analysis of the palmitoylation and membranetargeting domain of neuromodulin (GAP-43) by site-specific mutagenesis.Biochemistry. 1993 Oct 12;32(40):10714-9.[PMID:8399217]
[2] Caprini M, Gomis A, Cabedo H, Planells-Cases R, Belmonte C, Viana F,Ferrer-Montiel A. GAP43 stimulates inositol trisphosphate-mediated calciumrelease in response to hypotonicity. EMBO J. 2003 Jun 16;22(12):3004-14. PubMedPMID: 12805215; PubMed Central PMCID: PMC162146.[PMID:12805215]
Functional Description
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Sequence Annotation
Domain: 31 60 IQ.
Region: 1 4 Important for membrane binding.
Modified residue: 41 41 Phosphoserine; by PHK and PKC.
Modified residue: 181 181 Phosphothreonine.
Modified residue: 202 202 Phosphoserine; by CK2.
Modified residue: 203 203 Phosphoserine; by CK2.
Protein Length
238 AA.
Protein Sequence
(Canonical)
MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ  60
AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT  120
EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT  180
TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA    238
FASTA
(Canonical)
>LipidDB-9606-00040|P17677
MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQ
AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT
EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAAT
TPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Gene Ontology
GO:0030424; C:axon; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0031527; C:filopodium membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:LIFEdb
GO:0045202; C:synapse; IEA:UniProtKB-KW
GO:0016198; P:axon choice point recognition; IEA:Ensembl
GO:0045165; P:cell fate commitment; IEA:Ensembl
GO:0010001; P:glial cell differentiation; IEA:Ensembl
GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB
GO:0040008; P:regulation of growth; IEA:UniProtKB-KW
GO:0009611; P:response to wounding; TAS:ProtInc
GO:0042246; P:tissue regeneration; IEA:Ensembl
Interpro
InterPro; IPR000048; IQ_motif_EF-hand-BS
InterPro; IPR001422; Neuromodulin
InterPro; IPR017454; Neuromodulin_C
InterPro; IPR018947; Neuromodulin_gap-junction_N
InterPro; IPR018243; Neuromodulin_palmitoyl/P_site
Pfam
Pfam; PF00612; IQ;
Pfam; PF06614; Neuromodulin;
Pfam; PF10580; Neuromodulin_N;
SMART
SMART; SM00015; IQ;
PROSITE
PROSITE; PS50096; IQ;
PROSITE; PS00412; NEUROMODULIN_1;
PROSITE; PS00413; NEUROMODULIN_2;
PRINTS
PRINTS; PR00215; NEUROMODULIN;