Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00027
Entry Name
UniProt Accession
Theoretical PI
5.58
Molecular Weight
103134.34
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neuropilin-1
Protein Synonyms/Alias
Vascular endothelial cell growth factor 165 receptor; CD304;
Gene Name
NRP1
Gene Synonyms/Alias
NRP; VEGF165R;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
9
Canonical
ERGLPLLCAVLALVL
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Sequence Annotation
Topological domain: 22 856 Extracellular.
Transmembrane: 857 879 Helical.
Topological domain: 880 923 Cytoplasmic.
Domain: 27 141 CUB 1.
Domain: 147 265 CUB 2.
Domain: 275 424 F5/8 type C 1.
Domain: 431 583 F5/8 type C 2.
Domain: 645 811 MAM.
Metal binding site: 195 195 Calcium.
Metal binding site: 209 209 Calcium.
Metal binding site: 250 250 Calcium.
Protein Length
923 AA.
Protein Sequence
(Canonical)
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA  60
PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF  120
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTTPSGVIKS PGFPEKYPNS LECTYIVFVP  180
KMSEIILEFE SFDLEPDSNP PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS  240
GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN  300
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYKI  360
DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI TRFVRIKPAT WETGISMRFE  420
VYGCKITDYP CSGMLGMVSG LISDSQITSS NQGDRNWMPE NIRLVTSRSG WALPPAPHSY  480
INEWLQIDLG EEKIVRGIII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF  540
EGNNNYDTPE LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV  600
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF  660
CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH  720
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI  780
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD  840
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN  900
FELVDGVKLK KDKLNTQSTY SEA                                          923
FASTA
(Canonical)
>LipidDB-9606-00027|O14786
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
Gene Ontology
GO:0030424; C:axon; ISS:BHF-UCL
GO:0009986; C:cell surface; IEA:Ensembl
GO:0031410; C:cytoplasmic vesicle; TAS:BHF-UCL
GO:0005829; C:cytosol; IDA:BHF-UCL
GO:0005769; C:early endosome; ISS:BHF-UCL
GO:0005615; C:extracellular space; IDA:UniProt
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0030426; C:growth cone; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005883; C:neurofilament; IEA:Ensembl
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0043235; C:receptor complex; TAS:BHF-UCL
GO:0002116; C:semaphorin receptor complex; NAS:BHF-UCL
GO:0097443; C:sorting endosome; ISS:BHF-UCL
GO:0015026; F:coreceptor activity; TAS:BHF-UCL
GO:0019955; F:cytokine binding; NAS:BHF-UCL
GO:0019838; F:growth factor binding; IPI:UniProtKB
GO:0008201; F:heparin binding; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0017154; F:semaphorin receptor activity; NAS:BHF-UCL
GO:0038085; F:vascular endothelial growth factor binding; IPI:BHF-UCL
GO:0005021; F:vascular endothelial growth factor-activated receptor activity; ISS:BHF-UCL
GO:0001525; P:angiogenesis; IMP:BHF-UCL
GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; ISS:BHF-UCL
GO:0048844; P:artery morphogenesis; ISS:BHF-UCL
GO:0048846; P:axon extension involved in axon guidance; ISS:BHF-UCL
GO:0007411; P:axon guidance; NAS:BHF-UCL
GO:0007413; P:axonal fasciculation; IEA:Ensembl
GO:0060385; P:axonogenesis involved in innervation; ISS:BHF-UCL
GO:0021785; P:branchiomotor neuron axon guidance; IEA:Ensembl
GO:0007155; P:cell adhesion; IEA:InterPro
GO:0002042; P:cell migration involved in sprouting angiogenesis; ISS:BHF-UCL
GO:0007267; P:cell-cell signaling; TAS:ProtInc
GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IMP:BHF-UCL
GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:BHF-UCL
GO:0071679; P:commissural neuron axon guidance; ISS:BHF-UCL
GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl
GO:0016358; P:dendrite development; IEA:Ensembl
GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IEA:Ensembl
GO:0035767; P:endothelial cell chemotaxis; IMP:BHF-UCL
GO:0097102; P:endothelial tip cell fate specification; ISS:BHF-UCL
GO:0021612; P:facial nerve structural organization; IEA:Ensembl
GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IEA:Ensembl
GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IMP:BHF-UCL
GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:Ensembl
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0021675; P:nerve development; ISS:BHF-UCL
GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; ISS:BHF-UCL
GO:0001764; P:neuron migration; ISS:BHF-UCL
GO:0009887; P:organ morphogenesis; TAS:ProtInc
GO:0001569; P:patterning of blood vessels; ISS:BHF-UCL
GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:BHF-UCL
GO:0050918; P:positive chemotaxis; ISS:BHF-UCL
GO:0048842; P:positive regulation of axon extension involved in axon guidance; ISS:BHF-UCL
GO:0060301; P:positive regulation of cytokine activity; TAS:BHF-UCL
GO:0010595; P:positive regulation of endothelial cell migration; TAS:BHF-UCL
GO:0001938; P:positive regulation of endothelial cell proliferation; TAS:BHF-UCL
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:BHF-UCL
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL
GO:1902336; P:positive regulation of retinal ganglion cell axon guidance; ISS:BHF-UCL
GO:0014911; P:positive regulation of smooth muscle cell migration; TAS:BHF-UCL
GO:1902946; P:protein localization to early endosome; ISS:BHF-UCL
GO:0090259; P:regulation of retinal ganglion cell axon guidance; ISS:BHF-UCL
GO:0060627; P:regulation of vesicle-mediated transport; TAS:BHF-UCL
GO:0061441; P:renal artery morphogenesis; IEA:Ensembl
GO:0009611; P:response to wounding; IEA:Ensembl
GO:0061299; P:retina vasculature morphogenesis in camera-type eye; ISS:BHF-UCL
GO:0031290; P:retinal ganglion cell axon guidance; ISS:BHF-UCL
GO:0071526; P:semaphorin-plexin signaling pathway; NAS:BHF-UCL
GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl
GO:1902285; P:semaphorin-plexin signaling pathway involved in neuron projection guidance; ISS:BHF-UCL
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0002040; P:sprouting angiogenesis; ISS:BHF-UCL
GO:0061549; P:sympathetic ganglion development; ISS:BHF-UCL
GO:0097490; P:sympathetic neuron projection extension; ISS:BHF-UCL
GO:0097491; P:sympathetic neuron projection guidance; ISS:BHF-UCL
GO:0021637; P:trigeminal nerve structural organization; IEA:Ensembl
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:BHF-UCL
GO:0038190; P:VEGF-activated neuropilin signaling pathway; ISS:BHF-UCL
GO:1902378; P:VEGF-activated neuropilin signaling pathway involved in axon guidance; IEA:Ensembl
Interpro
InterPro; IPR000421; Coagulation_fac_5/8-C_type_dom
InterPro; IPR013320; ConA-like_dom
InterPro; IPR000859; CUB_dom
InterPro; IPR008979; Galactose-bd-like
InterPro; IPR000998; MAM_dom
InterPro; IPR014648; Neuropilin
InterPro; IPR022579; Neuropilin1_C
InterPro; IPR027146; NRP1
Pfam
Pfam; PF00431; CUB;
Pfam; PF11980; DUF3481;
Pfam; PF00754; F5_F8_type_C;
Pfam; PF00629; MAM;
SMART
SMART; SM00042; CUB;
SMART; SM00231; FA58C;
SMART; SM00137; MAM;
PROSITE
PROSITE; PS01180; CUB;
PROSITE; PS01285; FA58C_1;
PROSITE; PS01286; FA58C_2;
PROSITE; PS50022; FA58C_3;
PROSITE; PS00740; MAM_1;
PROSITE; PS50060; MAM_2;
PRINTS
PRINTS; PR00020; MAMDOMAIN;