Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00021
Entry Name
UniProt Accession
Theoretical PI
6.8
Molecular Weight
25416.06
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
CD9 antigen
Protein Synonyms/Alias
5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD9;
Gene Name
CD9
Gene Synonyms/Alias
MIC3; TSPAN29; GIG2;
Created Date
01-MAY-1991
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
9
Canonical
PVKGGTKCIKYLLFG
[1]
S-Palmitoylation
78
Canonical
MLVGFLGCCGAVQES
[1]
S-Palmitoylation
79
Canonical
LVGFLGCCGAVQESQ
[1]
S-Palmitoylation
87
Canonical
GAVQESQCMLGLFFG
[1]
S-Palmitoylation
218
Canonical
MIFSMILCCAIRRNR
[1]
S-Palmitoylation
219
Canonical
IFSMILCCAIRRNRE
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Stipp CS, Kolesnikova TV, Hemler ME. Functional domains in tetraspaninproteins. Trends Biochem Sci. 2003 Feb;28(2):106-12. Review. Erratum in: TrendsBiochem Sci. 2003 Mar;28(3):124.[PMID:12575999]
Functional Description
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.
Sequence Annotation
Topological domain: 2 12 Cytoplasmic.
Transmembrane: 13 33 Helical.
Topological domain: 34 55 Extracellular.
Transmembrane: 56 76 Helical.
Topological domain: 77 87 Cytoplasmic.
Transmembrane: 88 111 Helical.
Topological domain: 112 195 Extracellular.
Transmembrane: 196 221 Helical.
Topological domain: 222 228 Cytoplasmic.
Protein Length
228 AA.
Protein Sequence
(Canonical)
MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV  60
YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE  120
VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL NCCGLAGGVE QFISDICPKK DVLETFTVKS  180
CPDAIKEVFD NKFHIIGAVG IGIAVVMIFG MIFSMILCCA IRRNREMV               228
FASTA
(Canonical)
>LipidDB-9606-00021|P21926
MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGV
YILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKE
VQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKS
CPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
Gene Ontology
GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0005615; C:extracellular space; IDA:UniProt
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031092; C:platelet alpha granule membrane; TAS:Reactome
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007420; P:brain development; IEA:Ensembl
GO:0007155; P:cell adhesion; IDA:UniProtKB
GO:0006928; P:cellular component movement; IDA:UniProtKB
GO:0007342; P:fusion of sperm to egg plasma membrane; IDA:UniProtKB
GO:0032504; P:multicellular organism reproduction; TAS:Reactome
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl
GO:0014003; P:oligodendrocyte development; IEA:Ensembl
GO:0030913; P:paranodal junction assembly; ISS:UniProtKB
GO:0030168; P:platelet activation; NAS:UniProtKB
GO:0002576; P:platelet degranulation; TAS:Reactome
GO:0009414; P:response to water deprivation; IEA:Ensembl
GO:0007338; P:single fertilization; TAS:Reactome
Interpro
InterPro; IPR028977; CD81_LEL
InterPro; IPR000301; Tetraspanin
InterPro; IPR018499; Tetraspanin/Peripherin
InterPro; IPR018503; Tetraspanin_CS
InterPro; IPR008952; Tetraspanin_EC2
Pfam
Pfam; PF00335; Tetraspannin;
SMART
PROSITE
PROSITE; PS00421; TM4_1;
PRINTS
PRINTS; PR00259; TMFOUR;