LipidDB-9606-00006

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00006

Entry Name

SLAP2_HUMAN

UniProt Accession

Q9H6Q3; A8K648; E1P5U1; E1P5U2; Q5TH27; Q5TH28; Q8WY18; Q96QI4; Q9H135;

Theoretical PI

5.23

Molecular Weight

28585.36

Genbank Protein ID

AAL29204.1; AAL38197.1; AAL38198.1; BAB15201.1; BAF84202.1; CAI21397.1; CAI21397.1; CAI21398.1; CAI21398.1; CAI23504.1; CAI23504.1; CAI23505.1; CAI23505.1; EAW76116.1; EAW76117.1; EAW76118.1; EAW76119.1; AAH42041.1;

Genbank Nucleotide ID

AF326353; AF290985; AF290986; AK025645; AK291513; AL031662; AL050318; AL031662; AL050318; AL050318; AL031662; AL050318; AL031662; CH471077; CH471077; CH471077; CH471077; BC042041;

Protein Name

Src-like-adapter 2

Protein Synonyms/Alias

Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2;

Gene Name

SLA2

Gene Synonyms/Alias

C20orf156; SLAP2;

Created Date

23-APR-2003

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
2	Canonical	******MGSLPSRRK	[1]	N-Myristoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A,Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS,Wu J. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novelinhibitor of antigen receptor signaling. J Exp Med. 2001 Nov 5;194(9):1263-76.[PMID:11696592]

Functional Description

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Sequence Annotation

Domain: 32 92 SH3.
Domain: 94 191 SH2.
Region: 195 261 SLA C-terminal.

Protein Length

261 AA.

Protein Sequence
(Canonical)

MGSLPSRRKS LPSPSLSSSV QGQGPVTMEA ERSKATAVAL GSFPAGGPAE LSLRLGEPLT  60
IVSEDGDWWT VLSEVSGREY NIPSVHVAKV SHGWLYEGLS REKAEELLLL PGNPGGAFLI  120
RESQTRRGSY SLSVRLSRPA SWDRIRHYRI HCLDNGWLYI SPRLTFPSLQ ALVDHYSELA  180
DDICCLLKEP CVLQRAGPLP GKDIPLPVTV QRTPLNWKEL DSSLLFSEAA TGEESLLSEG  240
LRESLSFYIS LNDEAVSLDD A                                            261

FASTA
(Canonical)

>LipidDB-9606-00006|Q9H6Q3
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT
IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI
RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA
DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEG
LRESLSFYISLNDEAVSLDDA

Gene Ontology

GO:0005737; C:cytoplasm; TAS:UniProtKB
GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Ensembl
GO:0010008; C:endosome membrane; NAS:UniProtKB
GO:0005770; C:late endosome; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:UniProtKB
GO:0047485; F:protein N-terminus binding; IPI:UniProtKB
GO:0005070; F:SH3/SH2 adaptor activity; IDA:UniProtKB
GO:0050851; P:antigen receptor-mediated signaling pathway; TAS:UniProtKB
GO:0019724; P:B cell mediated immunity; TAS:UniProtKB
GO:0030522; P:intracellular receptor signaling pathway; TAS:UniProtKB
GO:0050869; P:negative regulation of B cell activation; TAS:UniProtKB
GO:0050849; P:negative regulation of calcium-mediated signaling; IDA:UniProtKB
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB
GO:0009967; P:positive regulation of signal transduction; IDA:GOC
GO:0050776; P:regulation of immune response; NAS:UniProtKB
GO:0042110; P:T cell activation; TAS:UniProtKB

Interpro

InterPro; IPR000980; SH2
InterPro; IPR001452; SH3_domain

Pfam

Pfam; PF00017; SH2;
Pfam; PF00018; SH3_1;

SMART

SMART; SM00252; SH2;
SMART; SM00326; SH3;

PROSITE

PROSITE; PS50001; SH2;
PROSITE; PS50002; SH3;

PRINTS

PRINTS; PR00401; SH2DOMAIN;