LipidDB ID

LipidDB-9103-01021

Entry Name

UniProt Accession

P07700;

Theoretical PI

9.31

Molecular Weight

54078.2

Genbank Protein ID

AAA49627.1;

Genbank Nucleotide ID

M14379;

Protein Name

Beta-1 adrenergic receptor

Protein Synonyms/Alias

Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-T;

Gene Name

ADRB1

Gene Synonyms/Alias

Created Date

01-APR-1988

Organism

Meleagris gallopavo (Common turkey)

NCBI Taxa ID

9103

Reference

[1] Warne T, Serrano-Vega MJ, Tate CG, Schertler GF. Development andcrystallization of a minimal thermostabilised G protein-coupled receptor. ProteinExpr Purif. 2009 Jun;65(2):204-13.[PMID:19297694]

Functional Description

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

Sequence Annotation

Topological domain: 1 38 Extracellular.
Transmembrane: 39 67 Helical; Name=1.
Topological domain: 68 76 Cytoplasmic.
Transmembrane: 77 103 Helical; Name=2.
Topological domain: 104 115 Extracellular.
Transmembrane: 116 137 Helical; Name=3.
Topological domain: 138 155 Cytoplasmic.
Transmembrane: 156 179 Helical; Name=4.
Topological domain: 180 205 Extracellular.
Transmembrane: 206 231 Helical; Name=5.
Topological domain: 232 285 Cytoplasmic.
Transmembrane: 286 315 Helical; Name=6.
Topological domain: 316 320 Extracellular.
Transmembrane: 321 343 Helical; Name=7.
Topological domain: 344 483 Cytoplasmic.
Region: 201 215 Agonist and antagonist binding.
Region: 303 310 Agonist and antagonist binding.
Region: 329 333 Agonist and antagonist binding.
Binding site: 121 121 Agonist or antagonist.
Binding site: 126 126 Agonist or antagonist.

Protein Length

483 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005769; C:early endosome; ISS:UniProtKB
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0004940; F:beta1-adrenergic receptor activity; IEA:InterPro
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB
GO:0005057; F:receptor signaling protein activity; ISS:UniProtKB
GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; ISS:UniProtKB
GO:0035556; P:intracellular signal transduction; ISS:GOC
GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:UniProtKB
GO:0043950; P:positive regulation of cAMP-mediated signaling; ISS:UniProtKB
GO:0045823; P:positive regulation of heart contraction; IEA:InterPro
GO:0032320; P:positive regulation of Ras GTPase activity; ISS:UniProtKB

Interpro

InterPro; IPR002233; ADR_fam
InterPro; IPR000507; ADRB1_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR01103; ADRENERGICR;
PRINTS; PR00561; ADRENRGCB1AR;
PRINTS; PR00237; GPCRRHODOPSN;