LipidDB ID

LipidDB-857306-01374

Entry Name

UniProt Accession

A0MD31;

Theoretical PI

7.98

Molecular Weight

7771.38

Genbank Protein ID

ABF66343.1;

Genbank Nucleotide ID

DQ489311;

Protein Name

Envelope small membrane protein

Protein Synonyms/Alias

Protein E; Glycoprotein 2b; Protein GP2b; Gs;

Gene Name

GP2b

Gene Synonyms/Alias

2b;

Created Date

28-JUN-2011

Organism

Porcine reproductive and respiratory syndrome virus (isolat Pig/United States/SD 01-08/2001) (PRRSV)

NCBI Taxa ID

857306

Reference

[1] Du Y, Zuckermann FA, Yoo D. Myristoylation of the small envelope protein ofporcine reproductive and respiratory syndrome virus is non-essential for virusinfectivity but promotes its growth. Virus Res. 2010 Feb;147(2):294-9. doi:10.1016/j.virusres.2009.11.016. Epub 2009 Nov 29.[PMID:19951726]

Functional Description

Minor envelope protein. May function as a viroporin in the virion envelope that facilitates uncoating of the virus in order to release the genomic RNA into the cytoplasm for subsequent replication (By similarity).

Sequence Annotation

Topological domain: 2 25 Virion surface.
Transmembrane: 26 46 Helical.
Topological domain: 47 70 Intravirion.
Region: 2 15 Endoplasmic reticulum retention signal.

Protein Length

70 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW
GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW
GO:0019031; C:viral envelope; IEA:UniProtKB-KW
GO:0005216; F:ion channel activity; IEA:UniProtKB-KW
GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW
GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW

Interpro

InterPro; IPR009775; PRRSV_2b

Pfam

Pfam; PF07069; PRRSV_2b;

SMART

PROSITE

PRINTS