| Tag |
Content |
LipidDB ID |
LipidDB-7955-01303 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
7.52 |
Molecular Weight |
47061.65 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Protein naked cuticle homolog 2 |
Protein Synonyms/Alias |
Naked-2; Protein naked cuticle homolog 2-A; Naked-2A; |
Gene Name |
nkd2 |
Gene Synonyms/Alias |
nkd2a; |
Created Date |
11-SEP-2007 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGKLHSKHA | [1] | N-Myristoylation |
|
Organism |
Danio rerio (Zebrafish) (Brachydanio rerio) |
NCBI Taxa ID |
7955 |
Reference |
[1] Hu T, Li C, Cao Z, Van Raay TJ, Smith JG, Willert K, Solnica-Krezel L, Coffey RJ. Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degradingDishevelled-1 at the plasma membrane. J Biol Chem. 2010 Apr 30;285(18):13561-8.doi: 10.1074/jbc.M109.075945. Epub 2010 Feb 20.[ PMID:20177058]
|
Functional Description |
Cell autonomous antagonist of both the canonical and non-canonical Wnt signaling pathways. |
Sequence Annotation |
Domain: 109 144 EF-hand.
|
Protein Length |
409 AA. |
Protein Sequence
(Canonical) |
MGKLHSKHAC KRRENPEGDS FVVNGFIAKR AAEEGERYGN NLKDYKNEEL KDSQPTLLHC 60
PLQVVLPPEK AEGCESFLQY LSPDDEERDA QKVTKRISLQ DLECNVSLAE DNRQEWVFTL 120
YDFDNSGKVT KEDMSSLMHT IYDVVDASVK HSCNSKRRSL RVKLSVTPEP AARRRDATHT 180
ERETSHLSQV EPVRSEEHRS ADRRQSTHIR GQTEAHEGNH YCVDENTERR NHYLDLAGIE 240
NYTSRFDSSS PDADQDPPSR SSHSQSRPHS QEPETHVYQR RSQLMEPCVA PDPRLRTGPQ 300
LIRSRSPKGS SRYPGVIPNV TKTSKCHGHH QPISAGQDVY HLTQQSHTHA HTPSGLQHSH 360
SRRIRSRARE QQALTPVKNT NATALVQRHE HHHHHEHHHH HHYHHYHQT 409
|
FASTA
(Canonical) |
>LipidDB-7955-01303|A4ZNR4
MGKLHSKHACKRRENPEGDSFVVNGFIAKRAAEEGERYGNNLKDYKNEELKDSQPTLLHC
PLQVVLPPEKAEGCESFLQYLSPDDEERDAQKVTKRISLQDLECNVSLAEDNRQEWVFTL
YDFDNSGKVTKEDMSSLMHTIYDVVDASVKHSCNSKRRSLRVKLSVTPEPAARRRDATHT
ERETSHLSQVEPVRSEEHRSADRRQSTHIRGQTEAHEGNHYCVDENTERRNHYLDLAGIE
NYTSRFDSSSPDADQDPPSRSSHSQSRPHSQEPETHVYQRRSQLMEPCVAPDPRLRTGPQ
LIRSRSPKGSSRYPGVIPNVTKTSKCHGHHQPISAGQDVYHLTQQSHTHAHTPSGLQHSH
SRRIRSRAREQQALTPVKNTNATALVQRHEHHHHHEHHHHHHYHHYHQT
|
Gene Ontology |
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0005509; F:calcium ion binding; IEA:InterPro GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IGI:ZFIN GO:0060061; P:Spemann organizer formation; IMP:ZFIN GO:0016055; P:Wnt signaling pathway; IGI:ZFIN |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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