Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-7227-01328
Entry Name
UniProt Accession
Theoretical PI
6.4
Molecular Weight
140722.1
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein prickle
Protein Synonyms/Alias
Protein spiny legs;
Gene Name
pk
Gene Synonyms/Alias
CG11084;
Created Date
29-MAY-2007
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
1296
Canonical
GGDKDKNCIIS****
[1]
S-Farnesylation
Organism
Drosophila melanogaster (Fruit fly)
NCBI Taxa ID
7227
Reference
[1] Strutt H, Thomas-MacArthur V, Strutt D. Strabismus promotes recruitment anddegradation of farnesylated prickle in Drosophila melanogaster planar polarityspecification. PLoS Genet. 2013;9(7):e1003654. doi: 10.1371/journal.pgen.1003654.Epub 2013 Jul 18.[PMID:23874239]
Functional Description
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.
Sequence Annotation
Domain: 515 623 PET.
Domain: 622 686 LIM zinc-binding 1.
Domain: 687 747 LIM zinc-binding 2.
Domain: 748 810 LIM zinc-binding 3.
Protein Length
1299 AA.
Protein Sequence
(Canonical)
MSSLSTGGGA GGSSGGPGGA DAAAAPAAGQ ATVTATGNME PAMVPRTANL LACKQWWRVC  60
FLYGDQQKYY RQLYSKAAAQ RLADANQEPD NARDREYDTV DCDLIAGQLD AVEDADDGID  120
LGDHSSTPKG GATTAGRPLF PHSSSPRRSK KLLRSLRAHV RGEKLPKNDT TTANESSEVT  180
QRNARVTVLD DPFLFGIDAD HLGDLVVRGK RYSTLDATEN MARFYAEQEA TAQVLEIIEQ  240
EEESPEQEAP KPALPPKQKQ QRPVPPLPPP PANRVTQDQG TQPAAPQVPL QPLTAGDLQF  300
LNLSLRQRSL PRSMKPFKDA HDISFTFNEL DTSAEPEVAT GAAQQESNEP ISRTPLTQIS  360
YLQKIPTLPR HFSPSGQGLA TPPALGSGGM GLPSSSSASA LYAAQAAAGI LPTSPLPLQR  420
HQQYLPPHHQ QHPGAGMGPG PGSGAAAGPP LGPQYSPGCS ANPKYSNAQL PPPPHHHHQL  480
SPALSTPSPP SLLHHPAGGT SSASAHAPFL GGPHMDMQRQ SHSDDDSGCA LEEYTWVPPG  540
LRPDQVRLYF SQIPDDKVPY VNSPGEQYRV RQLLHQLPPH DNEVRYCHSL TDEERKELRL  600
FSTQRKRDAL GRGNVRQLMS ARPCDGCDDL ISTGDIAVFA TRLGPNASWH PACFACSVCR  660
ELLVDLIYFH RDGRMYCGRH HAETLKPRCS ACDEIILADE CTEAEGRAWH MNHFACHECD  720
KQLGGQRYIM REGKPYCLHC FDAMFAEYCD YCGEAIGVDQ GQMSHDGQHW HATDECFSCN  780
TCRCSLLGRA FLPRRGAIYC SIACSKGEPP TPSDSSGTGM YTTPTPPTQR VRPHPQAPLP  840
ARIPSSHASS SPPMSPQQQQ QHQATFNQAM YQMQSQQMEA AGGLVDQSKS YAASDSDAGV  900
VKDLEHGGHM GGGDLTDFSG GRASSTSQNL SPLNSPGDFQ PHFLPKPMEL QRDGVYNFNE  960
MSSNLDAAWS AKPTNSYHLQ RQLLENPHTA SMPELAGKLV APPAHMQHLS QLHAVSSHQF  1020
QQHEYADILH PPPPPPGEIP ELPTPNLSVA STALPPELMG SPTHSAGDRS LNTPMSTQSA  1080
SHAPPHPVSI LSGASSSSPM SGEPAKKKGV RFEGIPDTLP RSRSYSGNGA GTSGGGERER  1140
DRDKDKEGGG RHGHGHSSRR RRRRKSSSSS SHHRSGSGHR SHSTTRADTY APAQPLSSSY  1200
QGPPSVLQAA NLVHESPSRQ QRERERERER EESEESDVCS TCSSSSSSSE DYMMMYQLPQ  1260
RRHYGGVRVS YVPNDALAYD RKRKPSELGG DKDKNCIIS                         1299
FASTA
(Canonical)
>LipidDB-7227-01328|A1Z6W3
MSSLSTGGGAGGSSGGPGGADAAAAPAAGQATVTATGNMEPAMVPRTANLLACKQWWRVC
FLYGDQQKYYRQLYSKAAAQRLADANQEPDNARDREYDTVDCDLIAGQLDAVEDADDGID
LGDHSSTPKGGATTAGRPLFPHSSSPRRSKKLLRSLRAHVRGEKLPKNDTTTANESSEVT
QRNARVTVLDDPFLFGIDADHLGDLVVRGKRYSTLDATENMARFYAEQEATAQVLEIIEQ
EEESPEQEAPKPALPPKQKQQRPVPPLPPPPANRVTQDQGTQPAAPQVPLQPLTAGDLQF
LNLSLRQRSLPRSMKPFKDAHDISFTFNELDTSAEPEVATGAAQQESNEPISRTPLTQIS
YLQKIPTLPRHFSPSGQGLATPPALGSGGMGLPSSSSASALYAAQAAAGILPTSPLPLQR
HQQYLPPHHQQHPGAGMGPGPGSGAAAGPPLGPQYSPGCSANPKYSNAQLPPPPHHHHQL
SPALSTPSPPSLLHHPAGGTSSASAHAPFLGGPHMDMQRQSHSDDDSGCALEEYTWVPPG
LRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPHDNEVRYCHSLTDEERKELRL
FSTQRKRDALGRGNVRQLMSARPCDGCDDLISTGDIAVFATRLGPNASWHPACFACSVCR
ELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGRAWHMNHFACHECD
KQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHATDECFSCN
TCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQRVRPHPQAPLP
ARIPSSHASSSPPMSPQQQQQHQATFNQAMYQMQSQQMEAAGGLVDQSKSYAASDSDAGV
VKDLEHGGHMGGGDLTDFSGGRASSTSQNLSPLNSPGDFQPHFLPKPMELQRDGVYNFNE
MSSNLDAAWSAKPTNSYHLQRQLLENPHTASMPELAGKLVAPPAHMQHLSQLHAVSSHQF
QQHEYADILHPPPPPPGEIPELPTPNLSVASTALPPELMGSPTHSAGDRSLNTPMSTQSA
SHAPPHPVSILSGASSSSPMSGEPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERER
DRDKDKEGGGRHGHGHSSRRRRRRKSSSSSSHHRSGSGHRSHSTTRADTYAPAQPLSSSY
QGPPSVLQAANLVHESPSRQQREREREREREESEESDVCSTCSSSSSSSEDYMMMYQLPQ
RRHYGGVRVSYVPNDALAYDRKRKPSELGGDKDKNCIIS
Gene Ontology
GO:0005737; C:cytoplasm; TAS:FlyBase
GO:0016020; C:membrane; NAS:FlyBase
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0008270; F:zinc ion binding; IEA:InterPro
GO:0009948; P:anterior/posterior axis specification; IMP:UniProtKB
GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase
GO:0042067; P:establishment of ommatidial planar polarity; IMP:FlyBase
GO:0001736; P:establishment of planar polarity; IMP:UniProtKB
GO:0045184; P:establishment of protein localization; TAS:FlyBase
GO:0007164; P:establishment of tissue polarity; IMP:UniProtKB
GO:0007163; P:establishment or maintenance of cell polarity; IMP:FlyBase
GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IMP:FlyBase
GO:0045185; P:maintenance of protein location; TAS:FlyBase
GO:0001738; P:morphogenesis of a polarized epithelium; IMP:FlyBase
GO:0045746; P:negative regulation of Notch signaling pathway; IMP:FlyBase
GO:0008104; P:protein localization; TAS:FlyBase
Interpro
InterPro; IPR010442; PET_domain
InterPro; IPR001781; Znf_LIM
Pfam
Pfam; PF00412; LIM;
Pfam; PF06297; PET;
SMART
SMART; SM00132; LIM;
PROSITE
PROSITE; PS00478; LIM_DOMAIN_1;
PROSITE; PS50023; LIM_DOMAIN_2;
PROSITE; PS51303; PET;
PRINTS