LipidDB ID

LipidDB-7227-00869

Entry Name

UniProt Accession

P38040; A4UZ90; Q540Y8; Q9V4Z3;

Theoretical PI

5.73

Molecular Weight

8130.26

Genbank Protein ID

AAA28570.1; AAF59030.1; AAM71087.1; AAM71088.1; AAM71089.1; AAM49858.1;

Genbank Nucleotide ID

M85042; AE013599; AE013599; AE013599; AE013599; AY118489;

Protein Name

Guanine nucleotide-binding protein subunit gamma-1

Protein Synonyms/Alias

Gene Name

Ggamma1

Gene Synonyms/Alias

G1; CG8261;

Created Date

01-OCT-1994

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Reference

[1] Yi P, Han Z, Li X, Olson EN. The mevalonate pathway controls heart formationin Drosophila by isoprenylation of Ggamma1. Science. 2006 Sep 1;313(5791):1301-3.Epub 2006 Jul 20.[PMID:16857902]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Sequence Annotation

Modified residue: 67 67 Cysteine methyl ester.

Protein Length

70 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005834; C:heterotrimeric G-protein complex; NAS:FlyBase
GO:0005886; C:plasma membrane; IDA:FlyBase
GO:0003924; F:GTPase activity; NAS:FlyBase
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0007015; P:actin filament organization; IMP:FlyBase
GO:0045176; P:apical protein localization; TAS:FlyBase
GO:0055059; P:asymmetric neuroblast division; IMP:FlyBase
GO:0007155; P:cell adhesion; IMP:FlyBase
GO:0061343; P:cell adhesion involved in heart morphogenesis; IMP:FlyBase
GO:0007391; P:dorsal closure; IMP:FlyBase
GO:0035050; P:embryonic heart tube development; IMP:FlyBase
GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:FlyBase
GO:0006184; P:GTP catabolic process; NAS:GOC
GO:0003015; P:heart process; IMP:FlyBase
GO:0022008; P:neurogenesis; IMP:FlyBase
GO:0007637; P:proboscis extension reflex; IMP:FlyBase
GO:0008360; P:regulation of cell shape; IMP:FlyBase

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS