LipidDB ID

LipidDB-7227-00787

Entry Name

UniProt Accession

P29503; Q26306; Q27273; Q8INP6; Q8INP7; Q960M1;

Theoretical PI

8.05

Molecular Weight

82325.25

Genbank Protein ID

CAA43806.1; AAB27151.1; AAB27147.1; AAA28403.1; AAF54330.1; AAF54326.2; AAN13406.1; AAN13407.1; AAK93411.1; AAO41451.1;

Genbank Nucleotide ID

X61617; S62597; S62583; L12218; AE014297; AE014297; AE014297; AE014297; AY051987; BT003772;

Protein Name

Protein neuralized

Protein Synonyms/Alias

Gene Name

neur

Gene Synonyms/Alias

neu; CG11988;

Created Date

01-APR-1993

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Reference

[1] Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R,Betschinger J, Knoblich JA, Teige M, Eisenhaber F. Experimental testing ofpredicted myristoylation targets involved in asymmetric cell division andcalcium-dependent signalling. Cell Cycle. 2008 Dec;7(23):3709-19. Epub 2008 Dec13. Erratum in: Cell Cycle. 2009 Feb 1;8(3):508-9.[PMID:19029837]

Functional Description

Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.

Sequence Annotation

Domain: 106 260 NHR 1.
Domain: 368 523 NHR 2.
Modified residue: 338 338 Phosphoserine.
Modified residue: 341 341 Phosphoserine.

Protein Length

754 AA.

Protein Sequence
(Isoform 3)

FASTA
(Isoform 3)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:FlyBase
GO:0005829; C:cytosol; TAS:Reactome
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase
GO:0005886; C:plasma membrane; IDA:FlyBase
GO:0003677; F:DNA binding; IEA:UniProtKB-KW
GO:1901981; F:phosphatidylinositol phosphate binding; IDA:FlyBase
GO:0004842; F:ubiquitin-protein transferase activity; IDA:FlyBase
GO:0008270; F:zinc ion binding; ISM:FlyBase
GO:0008356; P:asymmetric cell division; IMP:FlyBase
GO:0048854; P:brain morphogenesis; IMP:FlyBase
GO:0048749; P:compound eye development; IMP:FlyBase
GO:0007398; P:ectoderm development; TAS:FlyBase
GO:0030718; P:germ-line stem cell maintenance; IMP:FlyBase
GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase
GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase
GO:0046331; P:lateral inhibition; IMP:FlyBase
GO:0031987; P:locomotion involved in locomotory behavior; IMP:FlyBase
GO:0007616; P:long-term memory; IMP:FlyBase
GO:0007498; P:mesoderm development; IMP:FlyBase
GO:0007399; P:nervous system development; IMP:FlyBase
GO:0042048; P:olfactory behavior; IMP:FlyBase
GO:0030707; P:ovarian follicle cell development; TAS:FlyBase
GO:0007422; P:peripheral nervous system development; IMP:FlyBase
GO:0045747; P:positive regulation of Notch signaling pathway; TAS:FlyBase
GO:0051260; P:protein homooligomerization; IPI:FlyBase
GO:0008104; P:protein localization; IMP:FlyBase
GO:0000209; P:protein polyubiquitination; IDA:FlyBase
GO:0045314; P:regulation of compound eye photoreceptor development; IMP:FlyBase
GO:0008593; P:regulation of Notch signaling pathway; IMP:FlyBase
GO:0046532; P:regulation of photoreceptor cell differentiation; IMP:FlyBase
GO:0007423; P:sensory organ development; IMP:FlyBase
GO:0016360; P:sensory organ precursor cell fate determination; IMP:FlyBase
GO:0001964; P:startle response; IMP:FlyBase

Interpro

InterPro; IPR006573; NeuZ_dom
InterPro; IPR001841; Znf_RING
InterPro; IPR013083; Znf_RING/FYVE/PHD

Pfam

Pfam; PF07177; Neuralized;

SMART

SMART; SM00588; NEUZ;
SMART; SM00184; RING;

PROSITE

PROSITE; PS51065; NHR;
PROSITE; PS50089; ZF_RING_2;

PRINTS