LipidDB ID

LipidDB-7227-00300

Entry Name

UniProt Accession

P16554; B8A413; B8A419; Q8IPE9; Q961A6; Q9VLB8;

Theoretical PI

9.64

Molecular Weight

60614.17

Genbank Protein ID

AAA28730.1; AAF52776.1; AAN10693.1; ACL68752.1; ACL68758.1; AAK93152.1;

Genbank Nucleotide ID

M27815; AE014134; AE014134; BT056305; BT056311; AY051728;

Protein Name

Protein numb

Protein Synonyms/Alias

Gene Name

numb

Gene Synonyms/Alias

CG3779;

Created Date

01-AUG-1990

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Reference

[1] Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R,Betschinger J, Knoblich JA, Teige M, Eisenhaber F. Experimental testing ofpredicted myristoylation targets involved in asymmetric cell division andcalcium-dependent signalling. Cell Cycle. 2008 Dec;7(23):3709-19. Epub 2008 Dec13. Erratum in: Cell Cycle. 2009 Feb 1;8(3):508-9.[PMID:19029837]

Functional Description

Required in determination of cell fate during sensory organ formation in embryos. Functions in nuclei and seems to interact with nucleic acids.

Sequence Annotation

Domain: 81 208 PID.
Nucleotide-binding: 22 29 ATP.
Modified residue: 430 430 Phosphothreonine.
Modified residue: 537 537 Phosphoserine.
Modified residue: 543 543 Phosphoserine.

Protein Length

556 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0045180; C:basal cortex; NAS:FlyBase
GO:0045178; C:basal part of cell; NAS:FlyBase
GO:0005938; C:cell cortex; IDA:FlyBase
GO:0005737; C:cytoplasm; IDA:FlyBase
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0005112; F:Notch binding; TAS:FlyBase
GO:0008356; P:asymmetric cell division; NAS:FlyBase
GO:0055059; P:asymmetric neuroblast division; IMP:FlyBase
GO:0045165; P:cell fate commitment; TAS:FlyBase
GO:0001709; P:cell fate determination; NAS:FlyBase
GO:0007417; P:central nervous system development; TAS:FlyBase
GO:0051642; P:centrosome localization; IMP:FlyBase
GO:0035050; P:embryonic heart tube development; IGI:FlyBase
GO:0008347; P:glial cell migration; IMP:FlyBase
GO:0007507; P:heart development; TAS:FlyBase
GO:0061382; P:Malpighian tubule tip cell differentiation; IMP:FlyBase
GO:0042694; P:muscle cell fate specification; IMP:FlyBase
GO:0045746; P:negative regulation of Notch signaling pathway; TAS:FlyBase
GO:0007400; P:neuroblast fate determination; NAS:FlyBase
GO:0007405; P:neuroblast proliferation; IMP:FlyBase
GO:0007219; P:Notch signaling pathway; TAS:FlyBase
GO:0061320; P:pericardial nephrocyte differentiation; IMP:FlyBase
GO:0007422; P:peripheral nervous system development; TAS:FlyBase
GO:0045807; P:positive regulation of endocytosis; IMP:FlyBase
GO:0008104; P:protein localization; IMP:FlyBase
GO:0009786; P:regulation of asymmetric cell division; IMP:FlyBase
GO:0051960; P:regulation of nervous system development; IMP:FlyBase
GO:0050767; P:regulation of neurogenesis; IMP:FlyBase
GO:0008593; P:regulation of Notch signaling pathway; TAS:FlyBase
GO:0007622; P:rhythmic behavior; TAS:FlyBase
GO:0045035; P:sensory organ precursor cell division; IMP:FlyBase
GO:0016360; P:sensory organ precursor cell fate determination; TAS:FlyBase
GO:0007419; P:ventral cord development; NAS:FlyBase

Interpro

InterPro; IPR016698; Numb/numb-like
InterPro; IPR010449; Numb_domain
InterPro; IPR011993; PH_like_dom
InterPro; IPR006020; PTB/PI_dom

Pfam

Pfam; PF06311; NumbF;
Pfam; PF00640; PID;

SMART

SMART; SM00462; PTB;

PROSITE

PROSITE; PS01179; PID;

PRINTS