LipidDB-5833-01189

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-5833-01189

Entry Name

CRT_PLAFA

UniProt Accession

Q9N623; Q19AE2; Q3Y5Z4; Q3Y5Z5; Q3Y5Z6; Q68PG1; Q6X529; Q7KQ06; Q86M68; Q86M69; Q86M70; Q8T9R7; Q9N653; Q9NH61;

Theoretical PI

8.87

Molecular Weight

48675.23

Genbank Protein ID

AAF26926.1; AAF60271.1; AAF60272.1; AAF60273.1; AAF60274.1; AAF60275.1; AAO85506.1; AAO85507.1; AAO85508.1; AAU00067.1; AAL75580.1; AAZ81606.1; AAZ81607.1; AAZ81608.1; ABF82363.1; AAP79044.1;

Genbank Nucleotide ID

AF030694; AF233064; AF233065; AF233066; AF233067; AF233068; AF495376; AF495377; AF495378; AY651315; AF468006; DQ156107; DQ156108; DQ156109; DQ533840; AY254700;

Protein Name

Chloroquine resistance transporter

Protein Synonyms/Alias

PfCRT;

Gene Name

CRT

Gene Synonyms/Alias

Created Date

22-SEP-2009

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
301	Canonical	RNTVVENCGLGMAKL	[1]	S-Palmitoylation

Organism

Plasmodium falciparum

NCBI Taxa ID

5833

Reference

[1] Jones ML, Collins MO, Goulding D, Choudhary JS, Rayner JC. Analysis of proteinpalmitoylation reveals a pervasive role in Plasmodium development andpathogenesis. Cell Host Microbe. 2012 Aug 16;12(2):246-58. doi:10.1016/j.chom.2012.06.005.[PMID:22901544]

Functional Description

May regulate endogenous transporter.

Sequence Annotation

Topological domain: 1 58 Cytoplasmic.
Transmembrane: 59 79 Helical.
Topological domain: 80 90 Lumenal.
Transmembrane: 91 111 Helical.
Topological domain: 112 127 Cytoplasmic.
Transmembrane: 128 148 Helical.
Topological domain: 149 154 Lumenal.
Transmembrane: 155 175 Helical.
Topological domain: 176 178 Cytoplasmic.
Transmembrane: 179 199 Helical.
Topological domain: 200 209 Lumenal.
Transmembrane: 210 230 Helical.
Topological domain: 231 248 Cytoplasmic.
Transmembrane: 249 269 Helical.
Topological domain: 270 317 Lumenal.
Transmembrane: 318 338 Helical.
Topological domain: 339 346 Cytoplasmic.
Transmembrane: 347 367 Helical.
Topological domain: 368 377 Lumenal.
Transmembrane: 378 398 Helical.
Topological domain: 399 424 Cytoplasmic.

Protein Length

424 AA.

Protein Sequence
(Canonical)

MKFASKKNNQ KNSSKNDERY RELDNLVQEG NGSRLGGGSC LGKCAHVFKL IFKEIKDNIF  60
IYILSIIYLS VCVMNKIFAK RTLNKIGNYS FVTSETHNFI CMIMFFIVYS LFGNKKGNSK  120
ERHRSFNLQF FAISMLDACS VILAFIGLTR TTGNIQSFVL QLSIPINMFF CFLILRYRYH  180
LYNYLGAVII VVTIALVEMK LSFETQEENS IIFNLVLISA LIPVCFSNMT REIVFKKYKI  240
DILRLNAMVS FFQLFTSCLI LPVYTLPFLK QLHLPYNEIW TNIKNGFACL FLGRNTVVEN  300
CGLGMAKLCD DCDGAWKTFA LFSFFNICDN LITSYIIDKF STMTYTIVSC IQGPAIAIAY  360
YFKFLAGDVV REPRLLDFVT LFGYLFGSII YRVGNIILER KKMRNEENED SEGELTNVDS  420
IITQ                                                               424

FASTA
(Canonical)

>LipidDB-5833-01189|Q9N623
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005773; C:vacuole; IEA:UniProtKB-KW

Interpro

InterPro; IPR000620; DMT
InterPro; IPR017258; Transprt_Chloroquine_res

Pfam

Pfam; PF00892; EamA;

SMART

PROSITE

PRINTS