LipidDB ID

LipidDB-5693-00716

Entry Name

UniProt Accession

P07749; Q26256; Q26915; Q27055; Q94786; Q94797;

Theoretical PI

5.01

Molecular Weight

23735.82

Genbank Protein ID

CAA26599.1; AAB23113.2; CAA90898.1; AAA99985.1; BAA13411.1; AAB08762.1;

Genbank Nucleotide ID

X02838; S43664; Z54193; L26971; D87512; U70035;

Protein Name

Flagellar calcium-binding protein

Protein Synonyms/Alias

FCABP; 1F8 protein; 24 kDa antigen; 29 kDa flagella protein; ALC-1 antigen; F29; P24;

Gene Name

FCABP

Gene Synonyms/Alias

Created Date

01-AUG-1988

Organism

Trypanosoma cruzi

NCBI Taxa ID

5693

Reference

[1] Godsel LM, Engman DM. Flagellar protein localization mediated by acalcium-myristoyl/palmitoyl switch mechanism. EMBO J. 1999 Apr 15;18(8):2057-65.[PMID:10205160]
[2] Wingard JN, Ladner J, Vanarotti M, Fisher AJ, Robinson H, Buchanan KT, Engman DM, Ames JB. Structural insights into membrane targeting by the flagellarcalcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensorin Trypanosoma cruzi. J Biol Chem. 2008 Aug 22;283(34):23388-96. doi:10.1074/jbc.M803178200. Epub 2008 Jun 17.[PMID:18559337]

Functional Description

May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.

Sequence Annotation

Domain: 45 80 EF-hand 1.
Domain: 81 116 EF-hand 2.
Domain: 127 162 EF-hand 3.
Domain: 164 199 EF-hand 4.

Protein Length

211 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031514; C:motile cilium; IEA:UniProtKB-KW
GO:0005509; F:calcium ion binding; IEA:InterPro

Interpro

InterPro; IPR003299; Calflagin-bd
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom

Pfam

Pfam; PF13405; EF-hand_6;
Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS

PRINTS; PR01362; CALFLAGIN;