LipidDB ID

LipidDB-559292-01249

Entry Name

UniProt Accession

P19073; D6VYN1; Q05978;

Theoretical PI

6.3

Molecular Weight

21322.73

Genbank Protein ID

CAA36186.1; AAB67416.1; AAS56259.1; DAA09547.1;

Genbank Nucleotide ID

X51906; U19027; AY557933; BK006945;

Protein Name

Cell division control protein 42

Protein Synonyms/Alias

Suppressor of RHO3 protein 2;

Gene Name

CDC42

Gene Synonyms/Alias

SRO2; YLR229C; L8083.13;

Created Date

01-NOV-1990

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

NCBI Taxa ID

559292

Reference

[1] Finegold AA, Johnson DI, Farnsworth CC, Gelb MH, Judd SR, Glomset JA, Tamanoi F. Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not theDPR1 gene product. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4448-52. PubMedPMID: 2034682; PubMed Central PMCID: PMC51677.[PMID:2034682]

Functional Description

Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 188 188 Cysteine methyl ester.

Protein Length

191 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005935; C:cellular bud neck; IDA:SGD
GO:0005934; C:cellular bud tip; IDA:SGD
GO:0000329; C:fungal-type vacuole membrane; IDA:SGD
GO:0000131; C:incipient cellular bud site; IDA:SGD
GO:0043332; C:mating projection tip; IDA:SGD
GO:0031965; C:nuclear membrane; IDA:SGD
GO:0005886; C:plasma membrane; IDA:SGD
GO:0005940; C:septin ring; IDA:SGD
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:SGD
GO:0007118; P:budding cell apical bud growth; IMP:SGD
GO:0007119; P:budding cell isotropic bud growth; IMP:SGD
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0000747; P:conjugation with cellular fusion; IMP:SGD
GO:0030010; P:establishment of cell polarity; IMP:SGD
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD
GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD
GO:0045921; P:positive regulation of exocytosis; IMP:SGD
GO:0007124; P:pseudohyphal growth; IMP:SGD
GO:0007096; P:regulation of exit from mitosis; IMP:SGD
GO:0060178; P:regulation of exocyst localization; IMP:SGD
GO:0031384; P:regulation of initiation of mating projection growth; IMP:SGD
GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD
GO:0031106; P:septin ring organization; IMP:SGD
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;