| Tag |
Content |
LipidDB ID |
LipidDB-559292-01049 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.62 |
Molecular Weight |
12625.39 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Guanine nucleotide-binding protein subunit gamma |
Protein Synonyms/Alias |
|
Gene Name |
STE18 |
Gene Synonyms/Alias |
YJR086W; J1866; |
Created Date |
01-NOV-1990 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
106 | Canonical | MSNSNSVCCTLM*** | [1][2] | S-Palmitoylation | 107 | Canonical | SNSNSVCCTLM**** | [2][1] | S-Farnesylation |
|
Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID |
559292 |
Reference |
[1] Hirschman JE, Jenness DD. Dual lipid modification of the yeast ggamma subunit Ste18p determines membrane localization of Gbetagamma. Mol Cell Biol. 1999Nov;19(11):7705-11.[ PMID:10523659]
[2] Manahan CL, Patnana M, Blumer KJ, Linder ME. Dual lipid modification motifs inG(alpha) and G(gamma) subunits are required for full activity of the pheromoneresponse pathway in Saccharomyces cerevisiae. Mol Biol Cell. 2000Mar;11(3):957-68.[ PMID:10712512]
|
Functional Description |
Implicated in the pheromone A- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. |
Sequence Annotation |
Modified residue: 107 107 Cysteine methyl ester.
|
Protein Length |
110 AA. |
Protein Sequence
(Canonical) |
MTSVQNSPRL QQPQEQQQQQ QQLSLKIKQL KLKRINELNN KLRKELSRER ITASNACLTI 60
INYTSNTKDY TLPELWGYPV AGSNHFIEGL KNAQKNSQMS NSNSVCCTLM 110
MTSVQNSPRL QQPQEQQQQQ QQLSLKIKQL KLKRINELNN KLRKELSRER ITASNACLTI 60
INYTSNTKDY TLPELWGYPV AGSNHFIEGL KNAQKNSQMS NSNSVCCTLM 110
|
FASTA
(Canonical) |
>LipidDB-559292-01049|P18852
MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRKELSRERITASNACLTI
INYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNSNSVCCTLM
MTSVQNSPRLQQPQEQQQQQQQLSLKIKQLKLKRINELNNKLRKELSRERITASNACLTI
INYTSNTKDYTLPELWGYPVAGSNHFIEGLKNAQKNSQMSNSNSVCCTLM
|
Gene Ontology |
GO:0005737; C:cytoplasm; IDA:SGD GO:0005834; C:heterotrimeric G-protein complex; IDA:SGD GO:0005886; C:plasma membrane; IDA:SGD GO:0004871; F:signal transducer activity; IMP:SGD GO:0031684; P:heterotrimeric G-protein complex cycle; IMP:SGD GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD |
Interpro |
InterPro; IPR015898; G-protein_gamma-like_dom |
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|