LipidDB ID

LipidDB-559292-01046

Entry Name

UniProt Accession

P36017; D6W2F0;

Theoretical PI

5.25

Molecular Weight

23080.96

Genbank Protein ID

CAA53769.1; CAA82543.1; CAA64010.1; CAA99285.1; DAA10866.1;

Genbank Nucleotide ID

X76173; Z29338; X94335; Z74997; BK006948;

Protein Name

Vacuolar protein sorting-associated protein 21

Protein Synonyms/Alias

GTP-binding protein YPT51; Vacuolar protein-targeting protein 12;

Gene Name

VPS21

Gene Synonyms/Alias

VPS12; VPT12; YPT21; YPT51; YOR089C; YOR3154C;

Created Date

01-JUN-1994

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

NCBI Taxa ID

559292

Reference

[1] Horazdovsky BF, Busch GR, Emr SD. VPS21 encodes a rab5-like GTP bindingprotein that is required for the sorting of yeast vacuolar proteins. EMBO J. 1994Mar 15;13(6):1297-309.[PMID:8137814]

Functional Description

Required for protein transport to the vacuole. Involved in two vesicle trafficking steps to the prevacuolar compartment (PVC), regulating the docking of endosomes and Golgi vesicles to the PVC by interacting with PEP7/VAC1 on the PVC membrane and promoting SNARE complex formation.

Sequence Annotation

Nucleotide-binding: 14 21 GTP.
Nucleotide-binding: 62 66 GTP.
Nucleotide-binding: 120 123 GTP.
Motif: 36 44 Effector region.
Modified residue: 188 188 Phosphoserine.
Modified residue: 210 210 Cysteine methyl ester.

Protein Length

210 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005770; C:late endosome; IMP:SGD
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IEA:UniProtKB-KW
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:SGD
GO:0006897; P:endocytosis; IMP:SGD
GO:0006895; P:Golgi to endosome transport; IMP:SGD
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IGI:SGD
GO:0036258; P:multivesicular body assembly; IGI:SGD
GO:0036010; P:protein localization to endosome; IGI:SGD
GO:0006623; P:protein targeting to vacuole; IMP:SGD
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0000011; P:vacuole inheritance; IMP:SGD

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;