Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-559292-00950
Entry Name
UniProt Accession
Theoretical PI
5.0
Molecular Weight
63207.85
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Vacuolar protein 8
Protein Synonyms/Alias
Gene Name
VAC8
Gene Synonyms/Alias
YEB3; YEL013W;
Created Date
01-FEB-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGSCCSCLK
[3]
N-Myristoylation
4
Canonical
****MGSCCSCLKDS
[1][2]
S-Palmitoylation
5
Canonical
***MGSCCSCLKDSS
[1][2]
S-Palmitoylation
7
Canonical
*MGSCCSCLKDSSDE
[1][2]
S-Palmitoylation
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
NCBI Taxa ID
559292
Reference
[1] Peng Y, Tang F, Weisman LS. Palmitoylation plays a role in targeting Vac8p to specific membrane subdomains. Traffic. 2006 Oct;7(10):1378-87.[PMID:16978392]
[2] Nadolski MJ, Linder ME. Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3. J Biol Chem. 2009 Jun 26;284(26):17720-30.doi: 10.1074/jbc.M109.005447. Epub 2009 May 5.[PMID:19416974]
[3] Wang YX, Catlett NL, Weisman LS. Vac8p, a vacuolar protein with armadillorepeats, functions in both vacuole inheritance and protein targeting from thecytoplasm to vacuole. J Cell Biol. 1998 Mar 9;140(5):1063-74.[PMID:9490720]
Functional Description
Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
Sequence Annotation
Modified residue: 11 11 Phosphoserine.
Modified residue: 16 16 Phosphoserine.
Protein Length
578 AA.
Protein Sequence
(Canonical)
MGSCCSCLKD SSDEASVSPI ADNEREAVTL LLGYLEDKDQ LDFYSGGPLK ALTTLVYSDN  60
LNLQRSAALA FAEITEKYVR QVSREVLEPI LILLQSQDPQ IQVAACAALG NLAVNNENKL  120
LIVEMGGLEP LINQMMGDNV EVQCNAVGCI TNLATRDDNK HKIATSGALI PLTKLAKSKH  180
IRVQRNATGA LLNMTHSEEN RKELVNAGAV PVLVSLLSST DPDVQYYCTT ALSNIAVDEA  240
NRKKLAQTEP RLVSKLVSLM DSPSSRVKCQ ATLALRNLAS DTSYQLEIVR AGGLPHLVKL  300
IQSDSIPLVL ASVACIRNIS IHPLNEGLIV DAGFLKPLVR LLDYKDSEEI QCHAVSTLRN  360
LAASSEKNRK EFFESGAVEK CKELALDSPV SVQSEISACF AILALADVSK LDLLEANILD  420
ALIPMTFSQN QEVSGNAAAA LANLCSRVNN YTKIIEAWDR PNEGIRGFLI RFLKSDYATF  480
EHIALWTILQ LLESHNDKVE DLVKNDDDII NGVRKMADVT FERLQRSGID VKNPGSNNNP  540
SSNDNNSNNN DTGSEHQPVE DASLELYNIT QQILQFLH                          578
MGSCCSCLKD SSDEASVSPI ADNEREAVTL LLGYLEDKDQ LDFYSGGPLK ALTTLVYSDN  60
LNLQRSAALA FAEITEKYVR QVSREVLEPI LILLQSQDPQ IQVAACAALG NLAVNNENKL  120
LIVEMGGLEP LINQMMGDNV EVQCNAVGCI TNLATRDDNK HKIATSGALI PLTKLAKSKH  180
IRVQRNATGA LLNMTHSEEN RKELVNAGAV PVLVSLLSST DPDVQYYCTT ALSNIAVDEA  240
NRKKLAQTEP RLVSKLVSLM DSPSSRVKCQ ATLALRNLAS DTSYQLEIVR AGGLPHLVKL  300
IQSDSIPLVL ASVACIRNIS IHPLNEGLIV DAGFLKPLVR LLDYKDSEEI QCHAVSTLRN  360
LAASSEKNRK EFFESGAVEK CKELALDSPV SVQSEISACF AILALADVSK LDLLEANILD  420
ALIPMTFSQN QEVSGNAAAA LANLCSRVNN YTKIIEAWDR PNEGIRGFLI RFLKSDYATF  480
EHIALWTILQ LLESHNDKVE DLVKNDDDII NGVRKMADVT FERLQRSGID VKNPGSNNNP  540
SSNDNNSNNN DTGSEHQPVE DASLELYNIT QQILQFLH                          578
FASTA
(Canonical)
>LipidDB-559292-00950|P39968
MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDN
LNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKL
LIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKH
IRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEA
NRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKL
IQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRN
LAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILD
ALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATF
EHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNP
SSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQFLH
MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDN
LNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKL
LIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKH
IRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEA
NRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKL
IQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRN
LAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILD
ALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATF
EHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNP
SSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQFLH
Gene Ontology
GO:0000329; C:fungal-type vacuole membrane; IDA:SGD
GO:0071563; C:Myo2p-Vac17p-Vac8p transport complex; IDA:SGD
GO:0071561; C:nucleus-vacuole junction; IDA:SGD
GO:0043495; F:protein anchor; IMP:SGD
GO:0071255; P:CVT vesicle assembly; IMP:SGD
GO:0016236; P:macroautophagy; IMP:SGD
GO:0071562; P:nucleus-vacuole junction assembly; IMP:SGD
GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD
GO:0042144; P:vacuole fusion, non-autophagic; IMP:SGD
GO:0000011; P:vacuole inheritance; IMP:SGD
Interpro
InterPro; IPR011989; ARM-like
InterPro; IPR016024; ARM-type_fold
InterPro; IPR000225; Armadillo
Pfam
Pfam; PF00514; Arm;
SMART
SMART; SM00185; ARM;
PROSITE
PROSITE; PS50176; ARM_REPEAT;
PRINTS