LipidDB ID

LipidDB-559292-00868

Entry Name

UniProt Accession

P07560; D6VTM4;

Theoretical PI

6.61

Molecular Weight

23505.7

Genbank Protein ID

AAA35032.1; BAA09233.1; AAT92862.1; DAA12434.1;

Genbank Nucleotide ID

M16507; D50617; AY692843; BK006940;

Protein Name

Ras-related protein SEC4

Protein Synonyms/Alias

Suppressor of RHO3 protein 6;

Gene Name

SEC4

Gene Synonyms/Alias

SRO6; YFL005W;

Created Date

01-AUG-1988

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

NCBI Taxa ID

559292

Reference

[1] Trueblood CE, Ohya Y, Rine J. Genetic evidence for in vivo cross-specificityof the CaaX-box protein prenyltransferases farnesyltransferase andgeranylgeranyltransferase-I in Saccharomyces cerevisiae. Mol Cell Biol. 1993Jul;13(7):4260-75.[PMID:8321228]

Functional Description

Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP- bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.

Sequence Annotation

Nucleotide-binding: 27 34 GTP.
Nucleotide-binding: 75 79 GTP.
Nucleotide-binding: 133 136 GTP.
Motif: 49 57 Effector region.
Modified residue: 201 201 Phosphoserine.
Modified residue: 204 204 Phosphoserine.

Protein Length

215 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030478; C:actin cap; TAS:SGD
GO:0000131; C:incipient cellular bud site; IDA:SGD
GO:0043332; C:mating projection tip; IDA:SGD
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0030133; C:transport vesicle; IDA:SGD
GO:0031982; C:vesicle; IDA:SGD
GO:0005525; F:GTP binding; IDA:SGD
GO:0003924; F:GTPase activity; IDA:SGD
GO:0031321; P:ascospore-type prospore assembly; IMP:SGD
GO:0006914; P:autophagy; IMP:SGD
GO:0007121; P:bipolar cellular bud site selection; TAS:SGD
GO:0006887; P:exocytosis; IDA:SGD
GO:0006893; P:Golgi to plasma membrane transport; IMP:SGD
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0007107; P:membrane addition at site of cytokinesis; IMP:SGD
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD
GO:0006906; P:vesicle fusion; IMP:SGD

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;