Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-559292-00735
Entry Name
UniProt Accession
Theoretical PI
5.78
Molecular Weight
48828.2
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
26S protease regulatory subunit 4 homolog
Protein Synonyms/Alias
Tat-binding homolog 5;
Gene Name
RPT2
Gene Synonyms/Alias
YHS4; YTA5; YDL007W; D2920;
Created Date
01-FEB-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGQGVSSGQ
[1]
N-Myristoylation
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
NCBI Taxa ID
559292
Reference
[1] Kimura Y, Saeki Y, Yokosawa H, Polevoda B, Sherman F, Hirano H. N-Terminalmodifications of the 19S regulatory particle subunits of the yeast proteasome.Arch Biochem Biophys. 2003 Jan 15;409(2):341-8.[PMID:12504901]
Functional Description
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Has ATPase activity.
Sequence Annotation
Nucleotide-binding: 223 230 ATP.
Protein Length
437 AA.
Protein Sequence
(Canonical)
MGQGVSSGQD KKKKKGSNQK PKYEPPVQSK FGRKKRKGGP ATAEKLPNIY PSTRCKLKLL  60
RMERIKDHLL LEEEFVSNSE ILKPFEKKQE EEKKQLEEIR GNPLSIGTLE EIIDDDHAIV  120
TSPTMPDYYV SILSFVDKEL LEPGCSVLLH HKTMSIVGVL QDDADPMVSV MKMDKSPTES  180
YSDIGGLESQ IQEIKESVEL PLTHPELYEE MGIKPPKGVI LYGAPGTGKT LLAKAVANQT  240
SATFLRIVGS ELIQKYLGDG PRLCRQIFKV AGENAPSIVF IDEIDAIGTK RYDSNSGGER  300
EIQRTMLELL NQLDGFDDRG DVKVIMATNK IETLDPALIR PGRIDRKILF ENPDLSTKKK  360
ILGIHTSKMN LSEDVNLETL VTTKDDLSGA DIQAMCTEAG LLALRERRMQ VTAEDFKQAK  420
ERVMKNKVEE NLEGLYL                                                 437
FASTA
(Canonical)
>LipidDB-559292-00735|P40327
MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLL
RMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIV
TSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTES
YSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQT
SATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGER
EIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKK
ILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAK
ERVMKNKVEENLEGLYL
Gene Ontology
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IDA:SGD
GO:0008540; C:proteasome regulatory particle, base subcomplex; IDA:SGD
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0016887; F:ATPase activity; IDA:SGD
GO:0036402; F:proteasome-activating ATPase activity; IMP:SGD
GO:0006200; P:ATP catabolic process; IDA:GOC
GO:0070651; P:nonfunctional rRNA decay; IMP:SGD
GO:0043171; P:peptide catabolic process; IMP:SGD
GO:1901800; P:positive regulation of proteasomal protein catabolic process; IMP:GOC
GO:0045732; P:positive regulation of protein catabolic process; IDA:SGD
GO:0070682; P:proteasome regulatory particle assembly; IMP:SGD
GO:0031503; P:protein complex localization; IMP:SGD
GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD
Interpro
InterPro; IPR005937; 26S_Psome_P45
InterPro; IPR003593; AAA+_ATPase
InterPro; IPR003959; ATPase_AAA_core
InterPro; IPR003960; ATPase_AAA_CS
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00004; AAA;
SMART
SMART; SM00382; AAA;
PROSITE
PROSITE; PS00674; AAA;
PRINTS