LipidDB ID

LipidDB-559292-00025

Entry Name

UniProt Accession

P06780; D6W4G6;

Theoretical PI

5.97

Molecular Weight

23152.45

Genbank Protein ID

AAA34977.1; AAB68152.1; AAA74729.1; AAS56388.1; DAA11582.1;

Genbank Nucleotide ID

M15189; U25840; M15161; AY558062; BK006949;

Protein Name

GTP-binding protein RHO1

Protein Synonyms/Alias

Rho-type GTPase 1;

Gene Name

RHO1

Gene Synonyms/Alias

YPR165W; P9325.3;

Created Date

01-JAN-1988

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

NCBI Taxa ID

559292

Reference

[1] Inoue SB, Qadota H, Arisawa M, Watanabe T, Ohya Y. Prenylation of Rho1p isrequired for activation of yeast 1, 3-beta-glucan synthase. J Biol Chem. 1999 Dec31;274(53):38119-24.[PMID:10608882]

Functional Description

Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7.

Sequence Annotation

Nucleotide-binding: 17 24 GTP.
Nucleotide-binding: 64 68 GTP.
Nucleotide-binding: 122 125 GTP.
Motif: 39 47 Effector region.
Modified residue: 2 2 N-acetylserine.
Modified residue: 206 206 Cysteine methyl ester.

Protein Length

209 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0000148; C:1,3-beta-D-glucan synthase complex; IDA:SGD
GO:0005935; C:cellular bud neck; IDA:SGD
GO:0005934; C:cellular bud tip; IDA:SGD
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IDA:SGD
GO:0000131; C:incipient cellular bud site; IDA:SGD
GO:0043332; C:mating projection tip; IDA:SGD
GO:0005777; C:peroxisome; IDA:SGD
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:SGD
GO:0030036; P:actin cytoskeleton organization; IMP:SGD
GO:0031532; P:actin cytoskeleton reorganization; IGI:SGD
GO:0007117; P:budding cell bud growth; IMP:SGD
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0045807; P:positive regulation of endocytosis; IMP:SGD
GO:0090037; P:positive regulation of protein kinase C signaling; IDA:SGD
GO:0008361; P:regulation of cell size; IMP:SGD
GO:0090334; P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; IDA:SGD
GO:0060178; P:regulation of exocyst localization; IMP:SGD
GO:0060237; P:regulation of fungal-type cell wall organization; IMP:SGD
GO:0032880; P:regulation of protein localization; IMP:SGD
GO:0032889; P:regulation of vacuole fusion, non-autophagic; IMP:SGD
GO:0007264; P:small GTPase mediated signal transduction; IDA:SGD

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;