Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-559292-00003
Entry Name
UniProt Accession
Theoretical PI
4.36
Molecular Weight
19638.92
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Calcineurin subunit B
Protein Synonyms/Alias
Calcineurin regulatory subunit; Protein phosphatase 2B regulatory subunit;
Gene Name
CNB1
Gene Synonyms/Alias
YCN2; YCNB; YKL190W;
Created Date
01-MAY-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGAAPSKIV
[1][2]
N-Myristoylation
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
NCBI Taxa ID
559292
Reference
[1] Cyert MS, Thorner J. Regulatory subunit (CNB1 gene product) of yeastCa2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol Cell Biol. 1992 Aug;12(8):3460-9.[PMID:1321337]
[2] Connolly S, Kingsbury T. Regulatory subunit myristoylation antagonizescalcineurin phosphatase activation in yeast. J Biol Chem. 2012 Nov16;287(47):39361-8. doi: 10.1074/jbc.M112.366617. Epub 2012 Oct 1.[PMID:23027860]
Functional Description
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Sequence Annotation
Domain: 21 56 EF-hand 1.
Domain: 53 88 EF-hand 2.
Domain: 90 125 EF-hand 3.
Domain: 131 166 EF-hand 4.
Protein Length
175 AA.
Protein Sequence
(Canonical)
MGAAPSKIVD GLLEDTNFDR DEIERLRKRF MKLDRDSSGS IDKNEFMSIP GVSSNPLAGR  60
IMEVFDADNS GDVDFQEFIT GLSIFSGRGS KDEKLRFAFK IYDIDKDGFI SNGELFIVLK  120
IMVGSNLDDE QLQQIVDRTI VENDSDGDGR LSFEEFKNAI ETTEVAKSLT LQYDV       175
FASTA
(Canonical)
>LipidDB-559292-00003|P25296
MGAAPSKIVDGLLEDTNFDRDEIERLRKRFMKLDRDSSGSIDKNEFMSIPGVSSNPLAGR
IMEVFDADNSGDVDFQEFITGLSIFSGRGSKDEKLRFAFKIYDIDKDGFISNGELFIVLK
IMVGSNLDDEQLQQIVDRTIVENDSDGDGRLSFEEFKNAIETTEVAKSLTLQYDV
Gene Ontology
GO:0005955; C:calcineurin complex; IDA:SGD
GO:0005509; F:calcium ion binding; ISS:SGD
GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IMP:SGD
GO:0006873; P:cellular ion homeostasis; IMP:SGD
GO:0016311; P:dephosphorylation; IDA:GOC
GO:0031505; P:fungal-type cell wall organization; IMP:SGD
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom
Pfam
Pfam; PF13499; EF-hand_7;
SMART
SMART; SM00054; EFh;
PROSITE
PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;
PRINTS