Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-387161-00334
Entry Name
UniProt Accession
Theoretical PI
5.93
Molecular Weight
63118.63
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Hemagglutinin HA2 chain
Protein Synonyms/Alias
Gene Name
HA
Gene Synonyms/Alias
Created Date
21-JUL-1986
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
551
Canonical
AGISFWMCSNGSLQC
[1]
S-Palmitoylation
558
Canonical
CSNGSLQCRICI***
[1]
S-Palmitoylation
561
Canonical
GSLQCRICI******
[1]
S-Palmitoylation
Organism
Influenza A virus (strain A/Japan/305/1957 H2N2)
NCBI Taxa ID
387161
Reference
[1] Naeve CW, Williams D. Fatty acids on the A/Japan/305/57 influenza virushemagglutinin have a role in membrane fusion. EMBO J. 1990 Dec;9(12):3857-66.[PMID:2249653]
Functional Description
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin- independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Sequence Annotation
Topological domain: 16 525 Extracellular.
Transmembrane: 526 546 Helical.
Topological domain: 547 562 Cytoplasmic.
Functional site: 340 341 Cleavage; by host.
Protein Length
562 AA.
Protein Sequence
(Canonical)
MAIIYLILLF TAVRGDQICI GYHANNSTEK VDTNLERNVT VTHAKDILEK THNGKLCKLN  60
GIPPLELGDC SIAGWLLGNP ECDRLLSVPE WSYIMEKENP RDGLCYPGSF NDYEELKHLL  120
SSVKHFEKVK ILPKDRWTQH TTTGGSRACA VSGNPSFFRN MVWLTKEGSD YPVAKGSYNN  180
TSGEQMLIIW GVHHPIDETE QRTLYQNVGT YVSVGTSTLN KRSTPEIATR PKVNGQGGRM  240
EFSWTLLDMW DTINFESTGN LIAPEYGFKI SKRGSSGIMK TEGTLENCET KCQTPLGAIN  300
TTLPFHNVHP LTIGECPKYV KSEKLVLATG LRNVPQIESR GLFGAIAGFI EGGWQGMVDG  360
WYGYHHSNDQ GSGYAADKES TQKAFDGITN KVNSVIEKMN TQFEAVGKEF GNLERRLENL  420
NKRMEDGFLD VWTYNAELLV LMENERTLDF HDSNVKNLYD KVRMQLRDNV KELGNGCFEF  480
YHKCDDECMN SVKNGTYDYP KYEEESKLNR NEIKGVKLSS MGVYQILAIY ATVAGSLSLA  540
IMMAGISFWM CSNGSLQCRI CI                                           562
FASTA
(Canonical)
>LipidDB-387161-00334|P03451
MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTNLERNVTVTHAKDILEKTHNGKLCKLN
GIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLL
SSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKEGSDYPVAKGSYNN
TSGEQMLIIWGVHHPIDETEQRTLYQNVGTYVSVGTSTLNKRSTPEIATRPKVNGQGGRM
EFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAIN
TTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDG
WYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFGNLERRLENL
NKRMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEF
YHKCDDECMNSVKNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQILAIYATVAGSLSLA
IMMAGISFWMCSNGSLQCRICI
Gene Ontology
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0019031; C:viral envelope; IEA:UniProtKB-KW
GO:0075512; P:clathrin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW
GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW
GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro
GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW
Interpro
InterPro; IPR008980; Capsid_hemagglutn
InterPro; IPR013828; Hemagglutn_HA1_a/b_dom
InterPro; IPR013827; Hemagglutn_HA1_b-rbn_dom
InterPro; IPR000149; Hemagglutn_influenz_A
InterPro; IPR001364; Hemagglutn_influenz_A/B
InterPro; IPR013829; Hemagglutn_stalk
Pfam
Pfam; PF00509; Hemagglutinin;
SMART
PROSITE
PRINTS
PRINTS; PR00330; HEMAGGLUTN1;
PRINTS; PR00329; HEMAGGLUTN12;