| Tag |
Content |
LipidDB ID |
LipidDB-387139-00209 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.29 |
Molecular Weight |
63415.83 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Hemagglutinin HA2 chain |
Protein Synonyms/Alias |
|
Gene Name |
HA |
Gene Synonyms/Alias |
|
Created Date |
21-JUL-1986 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
555 | Canonical | LGFIMWACQRGNIRC | [1] | S-Palmitoylation | 562 | Canonical | CQRGNIRCNICI*** | [1] | S-Palmitoylation | 565 | Canonical | GNIRCNICI****** | [1] | S-Palmitoylation |
|
Organism |
Influenza A virus (strain A/Aichi/2/1968 H3N2) |
NCBI Taxa ID |
387139 |
Reference |
[1] Chen BJ, Takeda M, Lamb RA. Influenza virus hemagglutinin (H3 subtype)requires palmitoylation of its cytoplasmic tail for assembly: M1 proteins of two subtypes differ in their ability to support assembly. J Virol. 2005Nov;79(21):13673-84.[ PMID:16227287]
|
Functional Description |
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin- independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. |
Sequence Annotation |
Topological domain: 17 530 Extracellular.
Transmembrane: 531 551 Helical.
Topological domain: 552 566 Cytoplasmic.
Functional site: 345 346 Cleavage; by host.
|
Protein Length |
566 AA. |
Protein Sequence
(Canonical) |
MKTIIALSYI FCLALGQDLP GNDNSTATLC LGHHAVPNGT LVKTITDDQI EVTNATELVQ 60
SSSTGKICNN PHRILDGIDC TLIDALLGDP HCDVFQNETW DLFVERSKAF SNCYPYDVPD 120
YASLRSLVAS SGTLEFITEG FTWTGVTQNG GSNACKRGPG SGFFSRLNWL TKSGSTYPVL 180
NVTMPNNDNF DKLYIWGIHH PSTNQEQTSL YVQASGRVTV STRRSQQTII PNIGSRPWVR 240
GLSSRISIYW TIVKPGDVLV INSNGNLIAP RGYFKMRTGK SSIMRSDAPI DTCISECITP 300
NGSIPNDKPF QNVNKITYGA CPKYVKQNTL KLATGMRNVP EKQTRGLFGA IAGFIENGWE 360
GMIDGWYGFR HQNSEGTGQA ADLKSTQAAI DQINGKLNRV IEKTNEKFHQ IEKEFSEVEG 420
RIQDLEKYVE DTKIDLWSYN AELLVALENQ HTIDLTDSEM NKLFEKTRRQ LRENAEEMGN 480
GCFKIYHKCD NACIESIRNG TYDHDVYRDE ALNNRFQIKG VELKSGYKDW ILWISFAISC 540
FLLCVVLLGF IMWACQRGNI RCNICI 566
|
FASTA
(Canonical) |
>LipidDB-387139-00209|P03437
MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQ
SSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPD
YASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVL
NVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVR
GLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITP
NGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWE
GMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEG
RIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGN
GCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISC
FLLCVVLLGFIMWACQRGNIRCNICI
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0019031; C:viral envelope; IEA:UniProtKB-KW GO:0075512; P:clathrin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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