| Tag |
Content |
LipidDB ID |
LipidDB-385599-00335 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
4.93 |
Molecular Weight |
11056.62 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
|
Protein Synonyms/Alias |
Matrix protein 2; |
Gene Name |
M2 |
Gene Synonyms/Alias |
|
Created Date |
18-APR-2006 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
50 | Canonical | LDRLFFKCIYRFFEH | [1] | S-Palmitoylation |
|
Organism |
Influenza A virus (A/udorn/1972(H3N2)) |
NCBI Taxa ID |
385599 |
Reference |
[1] Grantham ML, Wu WH, Lalime EN, Lorenzo ME, Klein SL, Pekosz A. Palmitoylation of the influenza A virus M2 protein is not required for virus replication invitro but contributes to virus virulence. J Virol. 2009 Sep;83(17):8655-61. doi: 10.1128/JVI.01129-09. Epub 2009 Jun 24.[ PMID:19553312]
|
Functional Description |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation. |
Sequence Annotation |
|
Protein Length |
96 AA. |
Protein Sequence
(Canonical) |
MSLLTEVETP IRNEWGCRCN DSSDPLVVAA SIIGILHLIL WILDRLFFKC IYRFFEHGLK 60
RGPSTEGVPE SMREEYRKEQ QSAVDADDSH FVSIEL 96
|
FASTA
(Canonical) |
>LipidDB-385599-00335|Q20MD5
MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLK
RGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIEL
|
Gene Ontology |
GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-KW |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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