LipidDB ID

LipidDB-3702-01215

Entry Name

UniProt Accession

Q94KI8; Q948T1; Q9ZT83;

Theoretical PI

4.89

Molecular Weight

84873.35

Genbank Protein ID

BAB55460.1; AAK39554.1; AAD15312.1; AAD11598.1; CAB77841.1; AEE82337.1;

Genbank Nucleotide ID

AB053952; AF360372; AC005142; AF071527; AL161497; CP002687;

Protein Name

Two pore calcium channel protein 1

Protein Synonyms/Alias

Calcium channel protein 1; AtCCH1; Fatty acid oxygenation up-regulated protein 2; Voltage-dependent calcium channel protein TPC1; AtTPC1;

Gene Name

TPC1

Gene Synonyms/Alias

CCH1; FOU2; At4g03560; F9H3.19; T5L23.5;

Created Date

01-JUL-2008

Organism

Arabidopsis thaliana (Mouse-ear cress)

NCBI Taxa ID

3702

Reference

[1] Predicted from GPS-Lipid

Functional Description

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.

Sequence Annotation

Topological domain: 1 71 Cytoplasmic.
Transmembrane: 72 92 Helical; Name=S1 of repeat I.
Topological domain: 93 120 Vacuolar.
Transmembrane: 121 141 Helical; Name=S2 of repeat I.
Topological domain: 142 158 Cytoplasmic.
Transmembrane: 159 179 Helical; Name=S3 of repeat I.
Topological domain: 180 180 Vacuolar.
Transmembrane: 181 199 Helical; Voltage-sensor; Name=S4 ofrepeat I.
Topological domain: 200 218 Cytoplasmic.
Transmembrane: 219 239 Helical; Name=S5 of repeat I.
Topological domain: 240 245 Vacuolar.
Topological domain: 261 282 Vacuolar.
Transmembrane: 283 303 Helical; Name=S6 of repeat I.
Topological domain: 304 428 Cytoplasmic.
Transmembrane: 429 449 Helical; Name=S1 of repeat II.
Topological domain: 450 465 Vacuolar.
Transmembrane: 466 486 Helical; Name=S2 of repeat II.
Topological domain: 487 498 Cytoplasmic.
Transmembrane: 499 519 Helical; Name=S3 of repeat II.
Topological domain: 520 528 Vacuolar.
Transmembrane: 529 546 Helical; Voltage-sensor; Name=S4 ofrepeat II.
Topological domain: 547 557 Cytoplasmic.
Transmembrane: 558 578 Helical; Name=S5 of repeat II.
Topological domain: 579 615 Vacuolar.
Topological domain: 631 651 Vacuolar.
Transmembrane: 652 672 Helical; Name=S6 of repeat II.
Topological domain: 673 733 Cytoplasmic.
Domain: 322 357 EF-hand 1.
Domain: 363 398 EF-hand 2.
Modified residue: 1 1 N-acetylmethionine.

Protein Length

733 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005794; C:Golgi apparatus; IDA:TAIR
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0000325; C:plant-type vacuole; IDA:TAIR
GO:0005886; C:plasma membrane; TAS:TAIR
GO:0005774; C:vacuolar membrane; IDA:TAIR
GO:0005773; C:vacuole; IDA:TAIR
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0005245; F:voltage-gated calcium channel activity; IGI:TAIR
GO:0006816; P:calcium ion transport; IMP:TAIR
GO:0019722; P:calcium-mediated signaling; IMP:TAIR
GO:0080141; P:regulation of jasmonic acid biosynthetic process; IMP:TAIR
GO:0010119; P:regulation of stomatal movement; IMP:TAIR
GO:0009845; P:seed germination; IMP:TAIR

Interpro

InterPro; IPR027359; Channel_four-helix_dom
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR002048; EF_hand_dom
InterPro; IPR005821; Ion_trans_dom
InterPro; IPR028801; TPC1

Pfam

Pfam; PF13405; EF-hand_6;
Pfam; PF00520; Ion_trans;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS50222; EF_HAND_2;

PRINTS