Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-3702-01002
Entry Name
UniProt Accession
Theoretical PI
5.76
Molecular Weight
53706.91
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Hexokinase-1
Protein Synonyms/Alias
2.7.1.1; Protein GLUCOSE INSENSITIVE 2;
Gene Name
HXK1
Gene Synonyms/Alias
GIN2; At4g29130; F19B15.160;
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
12
Canonical
AVGATVVCTAAVCAV
[1]
S-Palmitoylation
17
Canonical
VVCTAAVCAVAVLVV
[1]
S-Palmitoylation
Organism
Arabidopsis thaliana (Mouse-ear cress)
NCBI Taxa ID
3702
Reference
[1] Predicted from GPS-Lipid
Functional Description
Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.
Sequence Annotation
Transmembrane: 4 24 Helical.
Domain: 42 240 Hexokinase type-1.
Domain: 249 487 Hexokinase type-2.
Nucleotide-binding: 101 106 ATP.
Region: 171 197 Glucose-binding.
Protein Length
496 AA.
Protein Sequence
(Canonical)
MGKVAVGATV VCTAAVCAVA VLVVRRRMQS SGKWGRVLAI LKAFEEDCAT PISKLRQVAD  60
AMTVEMHAGL ASDGGSKLKM LISYVDNLPS GDEKGLFYAL DLGGTNFRVM RVLLGGKQER  120
VVKQEFEEVS IPPHLMTGGS DELFNFIAEA LAKFVATECE DFHLPEGRQR ELGFTFSFPV  180
KQTSLSSGSL IKWTKGFSIE EAVGQDVVGA LNKALERVGL DMRIAALVND TVGTLAGGRY  240
YNPDVVAAVI LGTGTNAAYV ERATAIPKWH GLLPKSGEMV INMEWGNFRS SHLPLTEFDH  300
TLDFESLNPG EQILEKIISG MYLGEILRRV LLKMAEDAAF FGDTVPSKLR IPFIIRTPHM  360
SAMHNDTSPD LKIVGSKIKD ILEVPTTSLK MRKVVISLCN IIATRGARLS AAGIYGILKK  420
LGRDTTKDEE VQKSVIAMDG GLFEHYTQFS ECMESSLKEL LGDEASGSVE VTHSNDGSGI  480
GAALLAASHS LYLEDS                                                  496
FASTA
(Canonical)
>LipidDB-3702-01002|Q42525
MGKVAVGATVVCTAAVCAVAVLVVRRRMQSSGKWGRVLAILKAFEEDCATPISKLRQVAD
AMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQER
VVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPV
KQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRY
YNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDH
TLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHM
SAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKK
LGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGI
GAALLAASHSLYLEDS
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:TAIR
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IDA:TAIR
GO:0005634; C:nucleus; IDA:TAIR
GO:0009536; C:plastid; IDA:TAIR
GO:0005774; C:vacuolar membrane; IDA:TAIR
GO:0005773; C:vacuole; IDA:TAIR
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0008865; F:fructokinase activity; IDA:TAIR
GO:0004340; F:glucokinase activity; IDA:TAIR
GO:0004396; F:hexokinase activity; IDA:TAIR
GO:0008270; F:zinc ion binding; IDA:TAIR
GO:0046835; P:carbohydrate phosphorylation; IDA:GOC
GO:0051156; P:glucose 6-phosphate metabolic process; IDA:GOC
GO:0010255; P:glucose mediated signaling pathway; IMP:TAIR
GO:0006096; P:glycolytic process; IEA:UniProtKB-KW
GO:0019320; P:hexose catabolic process; IDA:TAIR
GO:0012501; P:programmed cell death; IMP:TAIR
GO:0090332; P:stomatal closure; IMP:TAIR
GO:0010182; P:sugar mediated signaling pathway; TAS:TAIR
GO:0010148; P:transpiration; IMP:TAIR
Interpro
InterPro; IPR001312; Hexokinase
InterPro; IPR022673; Hexokinase_C
InterPro; IPR019807; Hexokinase_CS
InterPro; IPR022672; Hexokinase_N
Pfam
Pfam; PF00349; Hexokinase_1;
Pfam; PF03727; Hexokinase_2;
SMART
PROSITE
PROSITE; PS00378; HEXOKINASES;
PRINTS
PRINTS; PR00475; HEXOKINASE;