LipidDB ID

LipidDB-3702-00886

Entry Name

UniProt Accession

O81445; O23603;

Theoretical PI

4.74

Molecular Weight

24553.98

Genbank Protein ID

AAC26008.1; CAB10542.1; CAB78765.1; AEE83921.1; BAC43389.1; AAO63987.1;

Genbank Nucleotide ID

AF076251; Z97343; AL161546; CP002687; AK118798; BT005567;

Protein Name

Calcineurin B-like protein 1

Protein Synonyms/Alias

SOS3-like calcium-binding protein 5;

Gene Name

CBL1

Gene Synonyms/Alias

SCABP5; At4g17615; dl4845w; FCAALL.122;

Created Date

21-DEC-2004

Organism

Arabidopsis thaliana (Mouse-ear cress)

NCBI Taxa ID

3702

Reference

[1] Batistic O, Sorek N, Schültke S, Yalovsky S, Kudla J. Dual fatty acylmodification determines the localization and plasma membrane targeting ofCBL/CIPK Ca2+ signaling complexes in Arabidopsis. Plant Cell. 2008May;20(5):1346-62. doi: 10.1105/tpc.108.058123. Epub 2008 May 23.[PMID:18502848]

Functional Description

Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses. May function as a positive regulator of salt and drought responses and as a negative regulator of cold response. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine- threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement. Involved in response to glucose and gibberellin during germination and seedling development and in response to cold stress. Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF.

Sequence Annotation

Domain: 31 66 EF-hand 1.
Domain: 67 102 EF-hand 2.
Domain: 104 139 EF-hand 3.
Domain: 148 183 EF-hand 4.
Functional site: 140 140 Involved in dimerization.
Modified residue: 201 201 Phosphoserine; by CIPK23.

Protein Length

213 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:TAIR
GO:0005886; C:plasma membrane; IDA:TAIR
GO:0005509; F:calcium ion binding; ISS:TAIR
GO:0019900; F:kinase binding; IPI:UniProtKB
GO:0009738; P:abscisic acid-activated signaling pathway; TAS:TAIR
GO:0019722; P:calcium-mediated signaling; TAS:TAIR
GO:0010107; P:potassium ion import; IGI:TAIR
GO:0009409; P:response to cold; IEP:TAIR
GO:0006970; P:response to osmotic stress; IMP:TAIR
GO:0009651; P:response to salt stress; IMP:TAIR
GO:0009414; P:response to water deprivation; IMP:TAIR
GO:0010118; P:stomatal movement; IGI:TAIR

Interpro

InterPro; IPR015757; Calcineur_B
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom

Pfam

Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS