| Tag |
Content |
LipidDB ID |
LipidDB-3702-00833 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.13 |
Molecular Weight |
25693.48 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Calcineurin B-like protein 4 |
Protein Synonyms/Alias |
Protein SALT OVERLY SENSITIVE 3; |
Gene Name |
CBL4 |
Gene Synonyms/Alias |
SOS3; At5g24270; MOP9.8; |
Created Date |
21-DEC-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGCSVSKKK | [1][2] | N-Myristoylation |
|
Organism |
Arabidopsis thaliana (Mouse-ear cress) |
NCBI Taxa ID |
3702 |
Reference |
[1] Ishitani M, Liu J, Halfter U, Kim CS, Shi W, Zhu JK. SOS3 function in plantsalt tolerance requires N-myristoylation and calcium binding. Plant Cell. 2000Sep;12(9):1667-78.[ PMID:11006339]
[2] Batistic O, Sorek N, Schültke S, Yalovsky S, Kudla J. Dual fatty acylmodification determines the localization and plasma membrane targeting ofCBL/CIPK Ca2+ signaling complexes in Arabidopsis. Plant Cell. 2008May;20(5):1346-62. doi: 10.1105/tpc.108.058123. Epub 2008 May 23.[ PMID:18502848]
|
Functional Description |
Acts as a calcium sensor involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance. Binding of a CBL protein to the regulatory NAF domain of a CIPK serine-threonine protein kinase lead to the activation of the kinase in a calcium-dependent manner. Operates in synergy with CIPK24/SOS2 to activate the plasma membrane Na(+)/H(+) antiporter SOS1. Involved in salt stress responses by mediating calcium-dependent microfilament reorganization. The CBL4/CIPK6 complex mediates translocation of AKT2 from the endoplasmic reticulum to the plasma membrane. Both myristoylation and S-acylation are required for AKT2 activation. |
Sequence Annotation |
Domain: 35 70 EF-hand 1.
Domain: 71 106 EF-hand 2.
Domain: 108 143 EF-hand 3.
Domain: 152 187 EF-hand 4.
Functional site: 144 144 Involved in dimerization.
Modified residue: 205 205 Phosphoserine.
|
Protein Length |
222 AA. |
Protein Sequence
(Canonical) |
MGCSVSKKKK KNAMRPPGYE DPELLASVTP FTVEEVEALY ELFKKLSSSI IDDGLIHKEE 60
FQLALFRNRN RRNLFADRIF DVFDVKRNGV IEFGEFVRSL GVFHPSAPVH EKVKFAFKLY 120
DLRQTGFIER EELKEMVVAL LHESELVLSE DMIEVMVDKA FVQADRKNDG KIDIDEWKDF 180
VSLNPSLIKN MTLPYLKDIN RTFPSFVSSC EEEEMELQNV SS 222
|
FASTA
(Canonical) |
>LipidDB-3702-00833|O81223
MGCSVSKKKKKNAMRPPGYEDPELLASVTPFTVEEVEALYELFKKLSSSIIDDGLIHKEE
FQLALFRNRNRRNLFADRIFDVFDVKRNGVIEFGEFVRSLGVFHPSAPVHEKVKFAFKLY
DLRQTGFIEREELKEMVVALLHESELVLSEDMIEVMVDKAFVQADRKNDGKIDIDEWKDF
VSLNPSLIKNMTLPYLKDINRTFPSFVSSCEEEEMELQNVSS
|
Gene Ontology |
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Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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