Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-3702-00808
Entry Name
UniProt Accession
Theoretical PI
9.51
Molecular Weight
35761.9
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Very-long-chain 3-oxoacyl-CoA reductase 1
Protein Synonyms/Alias
1.1.1.330; Beta-ketoacyl reductase 1; AtKCR1; Protein GLOSSY 8; gl8At;
Gene Name
KCR1
Gene Synonyms/Alias
At-YBR159; GL8; At1g67730; F12A21.31;
Created Date
28-NOV-2012
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
4
Canonical
****MEICTYFKSQP
[1]
S-Palmitoylation
Organism
Arabidopsis thaliana (Mouse-ear cress)
NCBI Taxa ID
3702
Reference
[1] Predicted from GPS-Lipid
Functional Description
Beta-ketoacyl-coenzyme A reductase required for the elongation of fatty acids precursors of sphingolipids, triacylglycerols, cuticular waxes and suberin. Responsible for the first reduction step in very long-chain fatty acids (VLCFAs) synthesis. Decreased expression of KCR1 (RNAi) leads to plants with fused vegetative and reproductive organs, and abnormal trichome, epidermal cell and root morphology. Cannot be complemented by KCR2.
Sequence Annotation
Transmembrane: 13 33 Helical.
Nucleotide-binding: 51 80 NADP.
Active site: 206 206 Proton acceptor.
Binding site: 191 191 Substrate.
Protein Length
318 AA.
Protein Sequence
(Canonical)
MEICTYFKSQ PTWLLILFVL GSISIFKFIF TLLRSFYIYF LRPSKNLRRY GSWAIITGPT  60
DGIGKAFAFQ LAQKGLNLIL VARNPDKLKD VSDSIRSKYS QTQILTVVMD FSGDIDEGVK  120
RIKESIEGLD VGILINNAGM SYPYAKYFHE VDEELINNLI KINVEGTTKV TQAVLPNMLK  180
RKKGAIINMG SGAAALIPSY PFYSVYAGAK TYVDQFTKCL HVEYKKSGID VQCQVPLYVA  240
TKMTKIRRAS FLVASPEGYA KAALRFVGYE AQCTPYWPHA LMGAVVSALP ESVFESFNIK  300
RCLQIRKKGL QKDSMKKE                                                318
FASTA
(Canonical)
>LipidDB-3702-00808|Q8L9C4
MEICTYFKSQPTWLLILFVLGSISIFKFIFTLLRSFYIYFLRPSKNLRRYGSWAIITGPT
DGIGKAFAFQLAQKGLNLILVARNPDKLKDVSDSIRSKYSQTQILTVVMDFSGDIDEGVK
RIKESIEGLDVGILINNAGMSYPYAKYFHEVDEELINNLIKINVEGTTKVTQAVLPNMLK
RKKGAIINMGSGAAALIPSYPFYSVYAGAKTYVDQFTKCLHVEYKKSGIDVQCQVPLYVA
TKMTKIRRASFLVASPEGYAKAALRFVGYEAQCTPYWPHALMGAVVSALPESVFESFNIK
RCLQIRKKGLQKDSMKKE
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IDA:TAIR
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:TAIR
GO:0018454; F:acetoacetyl-CoA reductase activity; IMP:TAIR
GO:0045703; F:ketoreductase activity; IDA:TAIR
GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR
GO:0042761; P:very long-chain fatty acid biosynthetic process; IMP:TAIR
Interpro
InterPro; IPR002198; DH_sc/Rdtase_SDR
InterPro; IPR002347; Glc/ribitol_DH
InterPro; IPR016040; NAD(P)-bd_dom
InterPro; IPR020904; Sc_DH/Rdtase_CS
Pfam
Pfam; PF00106; adh_short;
SMART
PROSITE
PROSITE; PS00061; ADH_SHORT;
PRINTS
PRINTS; PR00081; GDHRDH;
PRINTS; PR00080; SDRFAMILY;